High-Performance Liquid Chromatographic Assay for the Determination of Nilotinib in Human Plasma
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概要
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A precise and convenient high-performance liquid chromatography (HPLC) method has been estab-lished to assay nilotinib in human plasma. Chromatographic separation of nilotinib was performed on a LiChrosphere®100 RP-18(e) column (250 mm×4.0 mm, 5 μm) using a mixture of acetonitrile and 0.01 M phosphate buffer (pH 3.0) (42 : 58, v/v) under isocratic conditions at a flow rate of 1.0 ml/min with ultraviolet (UV) detection at 266 nm. The calibration curve showed linearity at concentrations between 250 ng/ml and 5000 ng/ml (r2>0.999). The mean±S.D. absolute recovery of nilotinib from plasma was 99.2±3.3%. The coefficients of variation of both intra- and inter-day precision were below 9.1%. These results indicate that this new HPLC-based quantification may be useful for therapeutic drug monitoring of nilotinib to help manage treatment in patients with chronic myeloid leukemia in clinical practice.
著者
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Hamada Akinobu
Department Of Pharmacy Kumamoto University Hospital
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Nambu Takeru
Department of Clinical Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto
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Yuki Misato
Department of Clinical Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto
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Kawaguchi Tatsuya
Department of Hematology and Infectious Diseases, Kumamoto University Hospital
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Saito Hideyuki
Department of Clinical Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto
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Kawaguchi Tatsuya
Department Of Hematology And Infectious Diseases Kumamoto University Graduate School Of Medical Scie
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Yamakawa Yuji
Department Of Pharmacy Kumamoto University Hospital
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Uchida Takashi
Department Of Oral Anatomy (2nd Division) School Of Dentistry Hiroshima University
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Uchida Takashi
Department Of Electronic Engineering National Defense Academy
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Uchida Takashi
Department of Electrical and Electronic Engineering, National Defense Academy
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Yamakawa Yuji
Department of Clinical Pharmaceutical Sciences, School of Pharmaceutical Sciences, Kumamoto University
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Yuki Misato
Department of Clinical Pharmaceutical Sciences, School of Pharmaceutical Sciences, Kumamoto University
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Saito Hideyuki
Department of Clinical Pharmaceutical Sciences, School of Pharmaceutical Sciences, Kumamoto University
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Uchida Takashi
Department of Clinical Pharmaceutical Sciences, School of Pharmaceutical Sciences, Kumamoto University
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