Rapid Amelioration of Hyperglycemia Facilitated by Dasatinib in a Chronic Myeloid Leukemia Patient with type 2 Diabetes Mellitus
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概要
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Tyrosine kinase inhibitors (TKIs) have been shown to affect glucose metabolism in patients with chronic myeloid leukemia (CML); however, their precise mechanism of action remains unknown. We herein report the case of a 57-year-old diabetic CML patient who was resistant to imatinib and initially required 20 units of insulin daily to control his blood glucose levels. After the initiation of dasatinib, the patient's insulin requirements declined rapidly and insulin treatment was discontinued within two weeks. Meanwhile, the fasting C-peptide immunoreactivity increased two-fold, suggesting that dasatinib facilitated the recovery of insulin production. Dasatinib may therefore be beneficial for diabetic CML patients, especially those who require insulin treatment.
著者
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Kawaguchi Tatsuya
Department Of Hematology And Infectious Diseases Kumamoto University Graduate School Of Medical Scie
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Ono Keiko
Department Of Applied Chemistry Okayama University
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Araki Eiichi
Department Of Metabolic Medicine Faculty Of Life Sciences Kumamoto University
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Watanabe Yuko
Department of Bacteriology and Pathology, Kanagawa Prefectural Public Health Laboratory
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Suzushima Hitoshi
Department of Hematology, Kumamoto Shinto General Hospital (formerly NTT West Kyushu Hospital), Japan
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Kikukawa Yoshitaka
Department of Hematology, Kumamoto Shinto General Hospital (formerly NTT West Kyushu Hospital), Japan
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Shimomura Taizou
Department of Hematology, Kumamoto Shinto General Hospital (formerly NTT West Kyushu Hospital), Japan
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Furukawa Noboru
Center for Medical Education and Research, Faculty of Life Sciences, Kumamoto University, Japan
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