Glucose Uptake in Rat Skeletal Muscle L6 Cells Is Increased by Low-Intensity Electrical Current Through the Activation of the Phosphatidylinositol-3-OH Kinase (PI-3K) / Akt Pathway
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概要
- 論文の詳細を見る
Activation of Akt by insulin is transmitted via phosphatidylinositol-3-OH kinase (PI-3K) and enhances glucose uptake. The PI-3K/Akt signaling is diminished in insulin resistance. Thus, approaches that activate PI-3K/Akt signaling leading to improved glucose uptake may ameliorate hyperglycemia. Here we showed that low-intensity electrical current or mild electrical stimulation (MES) activated the PI-3K/Akt signaling and increased the glucose uptake in rat skeletal muscle (L6) cells. The glucose uptake enhanced by MES in muscle cells, the major cells involved in glucose disposal, suggests MES may have a possible beneficial effect on hyperglycemia.
著者
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SATO Takashi
Department of Neurosurgery, University of Yamanashi, Faculty of Medicine
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SUICO Mary
Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Global COE Cell Fate R
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KOGA Tomoaki
Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Global COE Cell Fate R
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SHUTO Tsuyoshi
Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Global COE Cell Fate R
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KAI Hirofumi
Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Global COE Cell Fate R
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Yano Shuichiro
Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Global COE “Cell Fate
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Morino-Koga Saori
Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Global COE “Cell Fate
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Kondo Tatsuya
Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Japan
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Shimauchi Yuichiro
Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Global COE “Cell Fate
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Matsuyama Shingo
Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Global COE “Cell Fate
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Araki Eiichi
Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Japan
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Suico Mary
Department Of Molecular Medicine Graduate School Of Pharmaceutical Sciences Global Coe Cell Fate Reg
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Koga Tomoaki
Department Of Molecular Medicine Graduate School Of Pharmaceutical Sciences Global Coe Cell Fate Reg
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Shuto Tsuyoshi
Department Of Molecular Medicine Graduate School Of Pharmaceutical Sciences Global Coe Cell Fate Reg
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Araki Eiichi
Department Of Metabolic Medicine Faculty Of Medical And Pharmaceutical Sciences Kumamoto University
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Yano Shuichiro
Department Of Biological Science Graduate School Of Science Hiroshima University
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Kondo Tatsuya
Department Of Developmental Genetics Kumamoto University
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Kai Hirofumi
Department Of Molecular Medicine Faculty Of Pharmaceutical Sciences Kumamoto University
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Sato Takashi
Department Of Internal Medicine And Clinical Immunology Yokohama City University School Of Medicine
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Araki Eiichi
Department Of Metabolic Medicine Faculty Of Life Sciences Kumamoto University
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Suico Mary
Department Of Molecular Medicine Graduate School Of Pharmaceutical Sciences Global Coe "cell Fa
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Matsuyama Shingo
Department Of Molecular Medicine Graduate School Of Pharmaceutical Sciences Global Coe "cell Fa
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Sato Takashi
Department Of Communications And Computer Engineering Kyoto University
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Shuto Tsuyoshi
Department Of Molecular Medicine Graduate School Of Pharmaceutical Sciences Global Coe "cell Fa
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Yano Shuichiro
Department Of Molecular Medicine Graduate School Of Pharmaceutical Sciences Global Coe "cell Fa
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Shimauchi Yuichiro
Department Of Molecular Medicine Graduate School Of Pharmaceutical Sciences Global Coe "cell Fate Regulation Research And Education Unit" Kumamoto University
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Sato Takashi
Department Of Applied Biochemistry And Food Science Saga University
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Kai Hirofumi
Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Global COE "Cell Fate Regulation Research and Education Unit", Kumamoto University, Japan
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Suico Mary
Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Global COE "Cell Fate Regulation Research and Education Unit", Kumamoto University, Japan
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Yano Shuichiro
Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Global COE "Cell Fate Regulation Research and Education Unit", Kumamoto University, Japan
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Shimauchi Yuichiro
Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Global COE "Cell Fate Regulation Research and Education Unit", Kumamoto University, Japan
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Morino-Koga Saori
Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Global COE "Cell Fate Regulation Research and Education Unit", Kumamoto University, Japan
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Shuto Tsuyoshi
Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Global COE "Cell Fate Regulation Research and Education Unit", Kumamoto University, Japan
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Matsuyama Shingo
Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Global COE "Cell Fate Regulation Research and Education Unit", Kumamoto University, Japan
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