Ceramide Enhances Susceptibility of Membrane Phospholipids to Phospholipase A_2 through Modification of Lipid Organization in Platelet Membranes

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概要

• 論文の詳細を見る

• The effects of ceramide on agonist-stimulated phospholipase A_2 (PLA_2) activity were studied in platelets. Cell-permeable C_6-ceramide (N-hexanoylsphingosine) exogenously added to platelet suspension enhanced U46619-stimulated arachidonic acid release and lysophosphatidylcholine production. Treatment of platelets with sphingomyelinase also led to an enhancement of the release. The enhanced arachidonic acid release by exogenous ceramide was completely inhibited by methyl arachidonyl fluorophosphonate, a cytosolic PLA_2 inhibitor. However, U46619-stimulated PLA_2 activity was not significantly potentiated by ceramide. These results suggest that enrichment of ceramide in membranes causes modification of intermolecular organization, leading to increased susceptibility of substrate phospholipids to PLA_2.

• 社団法人日本薬学会の論文
• 1999-12-15

著者

• SATO Takashi

  Department of Neurosurgery, University of Yamanashi, Faculty of Medicine

• Sato T

  Department Of Pathological Biochemistry Kyoto Pharmaceutical University

• Sato Takashi

  京都薬科大学 病態生化学

• AKIBA Satoshi

  Department of Pathological Biochemistry, Kyoto Pharmaceutical University

• KAGEURA Tadashi

  Kyoto Pharmaceutical University

• KITATANI Kazuyuki

  Department of Pathological Biochemistry, Kyoto Pharmaceutical University

• HASHIZUME Tsutomu

  Department of Pathological Biochemistry, Kyoto Pharmaceutical University

• KAGEURA Tadashi

  Department of Pathological Biochemistry, Kyoto Pharmaceutical University

• HAYAMA Misako

  Department of Pathological Biochemistry, Kyoto Pharmaceutical University

• Hashizume T

  Iwate Univ. Morioka Jpn

• Hashizume T

  Department Of Pathological Biochemistry Kyoto Pharmceutical University

• Hashizume Tsutomu

  Department Of Pathological Biochemistry Kyoto Pharmaceutical University

• Kitatani Kazuyuki

  Department Of Pathological Biochemistry Kyoto Pharmaceutical University

• Akiba S

  Department Of Pathological Biochemistry Kyoto Pharmaceutical University

• Akiba Satoshi

  Department Of Pathological Biochemistry Kyoto Pharmaceutical University

• Hayama Misako

  Department Of Pathological Biochemistry Kyoto Pharmceutical University

• Kageura Tadashi

  Department Of Pathological Biochemistry Kyoto Pharmceutical University

• Sato Takashi

  Department Of Internal Medicine And Clinical Immunology Yokohama City University School Of Medicine

• Sato T

  Department Of Applied Chemistry Faculty Of Engineering Nagasaki University

• Sato T

  Department Of Biological Science And Technology Faculty Of Engineering The University Of Tokushima

• Sato Takashi

  Department Of Pathological Biochemistry Kyoto Pharmaceutical University

• Sato Takashi

  Department Of Communications And Computer Engineering Kyoto University

• Sato Takashi

  Department Of Applied Biochemistry And Food Science Saga University

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