Involvement of Lipoxygenase Pathway in Docosapentaenoic Acid-Induced Inhibition of Platelet Aggregation

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概要

• 論文の詳細を見る

• The effects of docosapentaenoic acid (DPA) on platelet aggregation and arachidonic acid metabolism were studied in comparison to those of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Collagen- or arachidonic acid-stimulated platelet aggregation was inhibited dose-dependently by n-3 fatty acids, among which DPA was the most potent inhibitor. These fatty acids inhibited U46619-induced aggregation but to almost the same extent. No effect of the acids on thrombin-induced aggregation was observed. Furthermore, these fatty acids suppressed thromboxane A_2 formation by platelets which were exposed to collagen or thrombin, or by platelets to which arachidonic acid was added. In these experiments also, DPA was the most potent inhibitor, whereas DHA was the most effective inhibitor of cyclooxygenase-1 activity. DPA enhanced formation of 12-hydroxyeicosatetraenoic acid in response to collagen or from arachidonic acid by intact platelets, while the other two acids had less of an effect. These results suggest that DPA possesses potent activity for interfering with the cyclooxygenase pathway and accelerating the lipoxygenase pathway, thus inhibiting platelet aggregation most effectively.

• 社団法人日本薬学会の論文
• 2000-11-01

著者

• SATO Takashi

  Department of Neurosurgery, University of Yamanashi, Faculty of Medicine

• Sato T

  Department Of Pathological Biochemistry Kyoto Pharmaceutical University

• Sato Takashi

  京都薬科大学 病態生化学

• AKIBA Satoshi

  Department of Pathological Biochemistry, Kyoto Pharmaceutical University

• KITATANI Kazuyuki

  Department of Pathological Biochemistry, Kyoto Pharmaceutical University

• MURATA Tatsunori

  Department of Pathological Biochemistry, Kyoto Pharmaceutical University

• Murata T

  Department Of Pathological Biochemistry Kyoto Pharmaceutical University

• Kitatani Kazuyuki

  Department Of Pathological Biochemistry Kyoto Pharmaceutical University

• Akiba S

  Department Of Pathological Biochemistry Kyoto Pharmaceutical University

• Akiba Satoshi

  Department Of Pathological Biochemistry Kyoto Pharmaceutical University

• Murata Tatsunori

  Department Of Pathological Biochemistry Kyoto Pharmaceutical University

• Sato Takashi

  Department Of Internal Medicine And Clinical Immunology Yokohama City University School Of Medicine

• Sato T

  Department Of Applied Chemistry Faculty Of Engineering Nagasaki University

• Sato T

  Department Of Biological Science And Technology Faculty Of Engineering The University Of Tokushima

• Sato Takashi

  Department Of Pathological Biochemistry Kyoto Pharmaceutical University

• Sato Takashi

  Department Of Communications And Computer Engineering Kyoto University

• Sato Takashi

  Department Of Applied Biochemistry And Food Science Saga University

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