Augmentation of Gene Expression and Production of Promatrix Metalloproteinase 2 by Propionibacterium acnes-Derived Factors in Hamster Sebocytes and Dermal Fibroblasts: A Possible Mechanism for Acne Scarring
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概要
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Aberrant extracellular matrix (ECM) remodeling in sebaceous glands and pilosebaceous units in the skin is associated with scar formation under acne conditions. To investigate the involvement of Propionibacterium acnes (P. acnes), a Gram-positive anaerobic microbial species, in ECM remodeling in sebaceous glands and pilosebaceous units, we examined the effects of P. acnes culture media, formalin-fixed P. acnes, and peptidoglycan (PGN) from Gram-positive bacteria walls on the production of promatrix metalloproteinase 2 (proMMP-2)/progelatinase A in hamster sebocytes and dermal fibroblasts. When hamster sebocytes (1.8×105 cells) and dermal fibroblasts (1×105 cells) were treated with P. acnes culture media and formalin-fixed P. acnes (corresponding to 1×106 and 1×107 bacterial cells), the production of proMMP-2 was augmented. In addition, PGN (5—50 μg/ml) dose-dependently augmented the production of proMMP-2 in both cells. Furthermore, the PGN (50 μg/ml)-augmented proMMP-2 production was resulted from an increase of its transcript. In contrast, there were no changes in cell proliferative activity in either the P. acnes or PGN-treated sebocytes and dermal fibroblasts, indicating that the augmented proMMP-2 production was not due to an increase in cell numbers. Therefore, these results provide novel evidence that PGN transcriptionally up-regulates the production of proMMP-2 in hamster sebocytes and dermal fibroblasts. Given an increase in the quantity of Gram-positive bacteria, including P. acnes in acne lesions, the aberrant ECM degradation may progress in sebaceous glands and pilosebaceous units, which is associated with acne scar formation.
著者
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Ito Akira
Department Of Biochemistry And Molecular Biology School Of Pharmacy Tokyo University Of Pharmacy And
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Noguchi Norihisa
Department Of Microbiology School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Sasatsu Masanori
Department Of Microbiology School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Sato Takashi
Department Of Internal Medicine And Clinical Immunology Yokohama City University School Of Medicine
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Kurihara Hirokazu
Department of Biochemistry and Molecular Biology, School of Pharmacy, Tokyo University of Pharmacy a
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Akimoto Noriko
Department of Biochemistry and Molecular Biology, School of Pharmacy, Tokyo University of Pharmacy a
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Sato Takashi
Department Of Applied Biochemistry And Food Science Saga University
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Akimoto Noriko
Department of Biochemistry and Molecular Biology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
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Kurihara Hirokazu
Department of Biochemistry and Molecular Biology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
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Sato Takashi
Department of Biochemistry and Molecular Biology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
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