Dietary Bisphenol A Suppresses the Growth of Newborn Pups by Insufficient Supply of Maternal Milk in Mice

概要

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Bisphenol A (BPA), a monomer used for the production of polycarbonate, is known to have estrogen activity. In this study, pregnant mice were fed chow diet containing 1 % BPA, and we examined the influence of dietary BPA on delivery and growth of newborn pups in mice. When pregnant mice were fed BPA diet, the mice normally delivered pups on day 21 of gestation. The number of offspring pups in maternal mice fed BPA diet was same to those fed normal diet. Therefore, the growth of fetuses and the process of delivery were not influenced by dietary BPA. However, the growth of newborn pups was markedly suppressed when maternal mice were fed BPA diet. The growth of neonatal mice depends on breast milk, and stomach was filled with milk in pups. In newborn pups from maternal mice supplemented with BPA diet, the weight of stomach was lower than that from maternal mice with normal diet. Since the serum level of prolactin was limited in maternal mice supplemented with BPA diet, the suppressed growth of newborn pups by dietary BPA may be due to the insufficient supply of breast milk. These results suggest that the influence of BPA on the growth of newborn pups is related to hormonal condition in maternal mice.
公益社団法人日本薬学会の論文
2004-06-01