Nobiletin, a Polymethoxy Flavonoid, Suppresses Bone Resorption by Inhibiting NFκB-Dependent Prostaglandin E Synthesis in Osteoblasts and Prevents Bone Loss Due to Estrogen Deficiency
スポンサーリンク
概要
- 論文の詳細を見る
Nobiletin, a polymethoxy flavonoid, prevents cancer and inflammation, but the roles of nobiletin in bone are unclear. We examined the effects of nobiletin on bone resorption in vitro and on bone mass in ovariectomized (OVX) mice in vivo. In vitro, nobiletin suppressed osteoclast formation and bone resorption induced by interleukin (IL)-1. Nobiletin suppressed the expression of cyclooxygenase-2, NFκB-dependent transcription, and prostaglandin E (PGE) production induced by IL-1 in osteoblasts. OVX mice showed severe bone loss in the femur by increased bone resorption due to estrogen deficiency, and nobiletin significantly restored the bone mass. Nobiletin could be beneficial to bone health in postmenopausal women.
著者
-
Matsumoto Chiho
Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology
-
Takita Morichika
Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology
-
Inada Masaki
Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology
-
Hirata Michiko
Department Of Biochemistry And Molecular Biology Tokyo University Of Pharmacy And Life Scienc : Bio-
-
Miyaura Chisato
Department Of Biotechnology And Life Science Tokyo University Of Agriculture And Technology
-
Harada Suguru
Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology
-
Tominari Tsukasa
Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Japan
-
Takita Morichika
Department Of Biotechnology And Life Science Tokyo University Of Agriculture And Technology
-
Inada Masaki
Department Of Biotechnology And Life Science Tokyo University Of Agriculture And Technology
-
Matsumoto Chiho
Department Of Biotechnology And Life Science Tokyo University Of Agriculture And Technology
-
Tominari Tsukasa
Department Of Biotechnology And Life Science Tokyo University Of Agriculture And Technology
-
Harada Suguru
Department Of Biotechnology And Life Science Tokyo University Of Agriculture And Technology
関連論文
- Role of Prostaglandin E in Receptor Activator of Nuclear Factor-κB Ligand (RANKL) Expression in Osteoblasts Induced by Cell Adhesion to Bone Marrow B-lymphocytes
- Prostaglandin E Receptor EP4 Antagonist Suppresses Lipopolysaccharide-Induced Osteoclast Formation and Inflammatory Bone Loss
- Nobiletin, a Polymethoxy Flavonoid, Suppresses Bone Resorption by Inhibiting NFκB-Dependent Prostaglandin E Synthesis in Osteoblasts and Prevents Bone Loss Due to Estrogen Deficiency
- Discoordinate Regulation of Expression of Matrix Metalloproteinases and Tissue Inhibitor of Metalloproteinases-3 in Bovine Endometrial Stromal Cells on Type-I Collagen Gel
- Inhibition of AP-1 binding activity and phosphatidylinositol 3-kinase pathway by nobiletin, a polymethoxy flavonoid, results in augmentation of TIMP-1 production and suppression of production of MMPs-1 and -9 in human fibrosarcoma HT-1080 cell
- Involvement of EMMPRIN/CD147 in pericellular proteolysis by augmenting the production of MMP-1 and localization of MMP-1 on tumor cell surface
- Cell Shape and Matrix Production of Fibroblasts Cultured on Fibroin-organized Silk Scaffold with Type-II β-turn Structured (Ala-Gly-Ala-Gly-Ser-Gly)n Sequences
- Suzaku Observations of the Hard X-Ray Variability of MCG -6-30-15 : the Effects of Strong Gravity around a Kerr Black Hole
- Purification, Molecular Cloning, and Genomic Organization of Human Brain Long-Chain Acyl-CoA Hydrolase
- Suzaku Observation of 1H0707-495 : Puzzling Spectral Drop around 7keV(Chapter 10. Super Massive Black Holes, The Extreme Universe in the Suzaku Era)
- Soybean isoflavones preserve bone mass in hindlimb-unloaded mice
- Discovery of Short-Timescale Variability of Seyfert 2 Galaxy NGC 6300 with XMM-Newton(Poster)
- Effect of Cu on the Corrosion Resistance of a NiMo_2B_2-Dispersed Ni-Based Alloy
- 1α,25-Dihydroxyvitamin D_3-26,23-lactam, a Novel Vitamin D_3 Analog, Acts as a Vitamin D_3 Antagonist in Human Prostate Cancer Cells
- Capsaicin, A Ligand for Vanilloid Receptor-1, Transduces Suppressive Signal for Osteoclast Differentiation in Bone
- B-Lymphocytes are Elevated in Mouse Bone Marrow by Estrogen Deficiency, and Induce Receptor Activator of Nuclear Factor κB Ligand (RANKL) Expression in Osteoblasts via Cell Adhesion
- Dietary Bisphenol A Suppresses the Growth of Newborn Pups by Insufficient Supply of Maternal Milk in Mice
- Naringin Suppresses Osteoclast Formation and Enhances Bone Mass in Mice
- Failure to Demonstrate the Stimulative Effect of Calcitonin on Cyclic AMP Accumulation in Avian Bone in Vitro
- Kinetics of Change in Casein Aggregation as a Result of Solvent-Induced Structural Change
- Nobiletin, a Polymethoxy Flavonoid, Suppresses Bone Resorption by Inhibiting NFκB-Dependent Prostaglandin E Synthesis in Osteoblasts and Prevents Bone Loss Due to Estrogen Deficiency
- Polymethoxy Flavonoids, Nobiletin and Tangeretin, Prevent Lipopolysaccharide-Induced Inflammatory Bone Loss in an Experimental Model for Periodontitis
- モデル動物を用いた閉経後骨粗鬆症と炎症性歯周病の関係解明
- Polymethoxy Flavonoids, Nobiletin and Tangeretin, Prevent Lipopolysaccharide-Induced Inflammatory Bone Loss in an Experimental Model for Periodontitis
- Discovery of Short-Timescale Variability of Seyfert 2 Galaxy NGC 6300 with XMM-Newton(Poster)
- Bombyx mori silk fibroin scaffolds for bone regeneration studied by bone differentiation experiment(BIOMEDICAL ENGINEERING)
- Genetic Analysis of the rat Na-K-2Cl Cotransporter (NKCC2) Gene in SHRSP/Izm:Positional Candidate Approach
- Matrix-Metalloproteinases-2 and -9 Production in Bovine Endometrial Cell Culture.
- Purification, Molecular Cloning, and Genomic Organization of Human Brain Long-Chain Acyl-CoA Hydrolase.
- The Protective Effects of β-Cryptoxanthin on Inflammatory Bone Resorption in a Mouse Experimental Model of Periodontitis