Polymethoxy Flavonoids, Nobiletin and Tangeretin, Prevent Lipopolysaccharide-Induced Inflammatory Bone Loss in an Experimental Model for Periodontitis
スポンサーリンク
概要
- 論文の詳細を見る
Nobiletin, a polymethoxy flavonoid (PMF), inhibits systemic bone resorption and maintains bone mass in estrogen-deficient ovariectomized mice. This study examined the anti-inflammatory effects of PMFs, nobiletin, and tangeretin on lipopolysaccharide (LPS)-induced bone resorption. Nobiletin and tangeretin suppressed LPS-induced osteoclast formation and bone resorption and suppressed the receptor activator of NF<I>κ</I>B ligand–induced osteoclastogenesis in RAW264.7 macrophages. Nobiletin clearly restored the alveolar bone mass in a mouse experimental model for periodontitis by inhibiting LPS-induced bone resorption. PMFs may therefore provide a new therapeutic approach for periodontal bone loss.
- 2012-08-20
著者
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Matsumoto Chiho
Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology
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Inada Masaki
Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology
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Hirata Michiko
Department Of Biochemistry And Molecular Biology Tokyo University Of Pharmacy And Life Scienc : Bio-
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Inada Masaki
Department Of Biotechnology And Life Science Tokyo University Of Agriculture And Technology
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Matsumoto Chiho
Department Of Biotechnology And Life Science Tokyo University Of Agriculture And Technology
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TOMINARI Tsukasa
Cooperative Major in Advanced Health Science, Tokyo University of Agriculture and Technology
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Tominari Tsukasa
Cooperative Major In Advanced Health Science Tokyo University Of Agriculture And Technology
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MIYAURA Chisato
Cooperative Major in Advanced Health Science, Tokyo University of Agriculture and Technology
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