Matrix-Metalloproteinases-2 and -9 Production in Bovine Endometrial Cell Culture.
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概要
- 論文の詳細を見る
In vitro cell culture is a convenient tool for studying cellular mechanisms. In the present study, production of matrix-metalloproteinases (MMPs) in bovine endometrial (containing both epithelial and stromal cells) monolayer cells was examined. Blastocysts attached to the endometrial cells in a monolayer culture were examined for their effects on MMP-2 production. Initial attachment of blastocysts to the monolayer inhibited MMP-2 production by endometrial cells. But once trophoblast cells began to migrate into the endometrial cell layer, MMP-2 production increased, and at the same time MMP-9 production also became evident in the medium. In order to understand how blastocysts affected MMP-2 production, we examined the effect of progesterone, estradiol, insulin-like growth factors (IGFs), tumor necrosis factors (TNFs), and interferon-tau (IFN-τ) supplementation. It was IFN-τ that inhibited the production of MMP-2. In addition, progesterone at a lower dose appeared to inhibit MMP-2 production. Both TNF-α and TNF-β strongly stimulated the production of MMP-2 and MMP-9, whereas IGFs had no effect. Based on these findings, it appears that conceptus has the capacity to inhibit MMP activity.
- 日本繁殖生物学会の論文
著者
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Hirata Michiko
Department Of Biochemistry And Molecular Biology Tokyo University Of Pharmacy And Life Scienc : Bio-
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Hashizume Kazuyoshi
Laboratory Of Animal Reproduction Faculty Of Agriculture Tohoku University
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Ito Akira
Department Of Biochemistry And Molecular Biology School Of Pharmacy Tokyo University Of Pharmacy And
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TAKAHASHI Toru
Laboratory of Reproductive Biology and Technology, Depar
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Shimada Arata
Laboratory Of Cell And Developmental Biology Faculty Of Bioscience And Biotechnology Tokyo Institute
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SHIMIZU Manabu
National Agricultural Research Center for Tohoku Region
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Sato Takashi
Department Of Applied Biochemistry And Food Science Saga University
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HIRATA Michiko
Department of Biochemistry, Tokyo University of Pharmacy and Life Science
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TODOROKI Junichi
Kagoshima Prefectural Cattle Breeding and Developmental Institute
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