Induction of Heparanase Gene Expression in Ventricular Myocardium of Rats with Isoproterenol-Induced Cardiac Hypertrophy(Pharmacology)
スポンサーリンク
概要
- 論文の詳細を見る
Gene expression of heparanase, matrix metalloproteinases (MMP)-2 and MMP-9 were examined in ventricles after chronic treatment with isoproterenol (ISO) induced cardiac hypertrophy in rats. Rats were treated with ISO (4mg/kg, intraperitoneal) twice daily for 4d. Ventricle weight of the heart and the ventricle weight/body weight ratio were increased respectively by 22% and 25% compared with control rats. Histology showed considerable cardiomyocyte hypertrophy in the ISO-treated rats in comparison to control rats. Northern blot hybridization revealed that heparanase and MMP-2 gene transcripts increased significantly in the ventricles of ISO-treated rats, whereas MMP-9 gene expression was not induced. Thus, heparanase and MMP-2 gene expressions are induced in the ventricle after chronic treatment with ISO, indicating that they might play an important role in development of ISO-induced cardiac hypertrophy.
- 公益社団法人日本薬学会の論文
- 2005-12-01
著者
-
木崎 景一郎
岩手大学農学部獣医生理学
-
HASHIZUME Kazuyoshi
Laboratory of Reproductive Endocrinology, National Institute Animal Industry
-
橋爪 一善
岩手大学農学部獣医生理学
-
橋爪 一善
岐阜大学大学院連合獣医学研究科:岩手大学農学部獣医学科基礎獣医学講座
-
橋爪 一善
独立行政法人農業生物資源研究所発生分化研究グループ生殖再生研究チーム
-
木崎 景一郎
北里大学獣医畜産学部獣医薬理学研究室:岩手大学農学部獣医生理学研究室
-
ITO Ryoichi
Department of Physics, Meiji University
-
Hara Yukio
Department Of Veterinary Pharmacology School Of Veterinary Medicine And Animal Sciences Kitasato Uni
-
Hashizume K
National Inst. Animal Ind. Ibaraki
-
Hashizume Kazuyoshi
Laboratory Of Veterinary Physiology Department Of Veterinary Medicine Faculty Of Agriculture Iwate U
-
Hashizume Kazuyoshi
Laboratory Of Animal Reproduction Faculty Of Agriculture Tohoku University
-
Hashizume Kazuyoshi
Laboratory Of Veterinary Physiology Department Of Veterinary Medicine Iwate University
-
Okada Muneyoshi
Department Of Veterinary Pharmacology Graduate School Of Agriculture And Life Sciences The Universit
-
Okada Muneyoshi
Department Of Veterinary Pharmacology School Of Veterinary Medicine And Animal Sciences Kitasato Uni
-
Ito Ryoichi
Department Of Veterinary Pharmacology School Of Veterinary Medicine And Animal Sciences Kitasato Uni
-
Ito Ryoichi
Department Of Applied Physics Faculty Of Engineering The University Of Tokyo
-
KIZAKI Keiichiro
Department of Veterinary Pharmacology, School of Veterinary Medicine and Animal Sciences, Kitasato U
-
YOSHIOKA Kazuki
Department of Veterinary Anatomy, School of Veterinary Medicine and Animal Sciences, Kitasato Univer
-
MUTOH Kenichiro
Department of Veterinary Anatomy, School of Veterinary Medicine and Animal Sciences, Kitasato Univer
-
Yoshioka Kazuki
Department Of Veterinary Anatomy School Of Veterinary Medicine And Animal Sciences Kitasato Universi
-
Hashizume Kazuyoshi
Laboratory Of Veterinary Physiology Department Of Veterinary Medicine Faculty Of Agriculture Iwate U
-
Mutoh Kenichiro
Department Of Veterinary Anatomy School Of Veterinary Medicine And Animal Sciences Kitasato Universi
-
Kizaki Kei-ichiro
Department Of Veterinary Pharmacology School Of Veterinary Medicine And Animal Sciences Kitasato Uni
-
Kizaki Keiichiro
Laboratory Of Veterinary Physiology Department Of Veterinary Medicine Faculty Of Agriculture Iwate U
-
Kizaki Keiichiro
Department Of Veterinary Pharmacology School Of Veterinary Medicine And Animal Sciences Kitasato Uni
-
Kizaki Keiichiro
Department Of Clinical Biochemistry Faculty Of Pharmaceutical Sciences Teikyo University
-
Yoshioka Kazuki
Department Of Veterinary Anatomy School Of Veterinary Medicine & Animal Science Kitasato Univers
-
Ito Ryoichi
Department Of Applied Physics Faculty And Engineering University Of Tokyo
-
Hashizume Kazuyoshi
Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Iwate University
関連論文
- Differences in tyrosine hydroxylase expression after short-term hypoxia, hypercapnia or hypercapnic hypoxia in rat carotid body
- Effects of Captopril and Telmisartan on Matrix Metalloproteinase-2 and -9 Expressions and Development of Left Ventricular Fibrosis Induced by Isoprenaline in Rats
- ウシ妊娠期の大型黄体細胞における暗調顆粒の超微形態学的特性とリラキシン免疫局在
- Methylglyoxal Enhances Sodium Nitroprusside–Induced Relaxation in Rat Aorta
- クローンウシ胎仔における Leptin 遺伝子、POU5F1遺伝子CpGアイランドのエピジェネティック状況の解析
- クローン牛胎児の組織、およびドナー細胞のDNAメチル化プロフィール
- 細胞非接着性培養プレートによるウシ子宮内膜間質細胞のスフェロイド作製
- 時間分解蛍光免疫測定法による牛の血漿中エストラジオール17β濃度の直接判定(臨床繁殖学)
- 時間分解蛍光免疫測定法によるニホンジカ糞中プロジェステロン測定(臨床繁殖学)
- ウシ子宮内膜培養細胞におけるマトリックスメタロプロテナーゼ2および9の産生
- 子宮内膜および栄養膜細胞におけるEMMPRINの発現とその分子機能解析
- B26 コラーゲンゲルによるウシ子宮内膜間質細胞の3次元培養におけるMMPsおよびTIMPs発現調節
- 表皮角化細胞での恒常的なMAILの発現におけるNF-κBの役割(生化学)
- イヌBRCA2遺伝子座のエキソン27領域に存在する遺伝的多型の解析(生化学)
- ウシ子宮内膜培養細胞におけるマトリックスメタロプロテナーゼ2および9の産生
- 着床に伴うウシ子宮内膜細胞外マトリックスの特異的動態
- Observation of Band Alignment Transition from Type-I to Type-II in AlInAs/AlGaAs Self-assembled Quantum Dots
- Fabrication of Periodically Domain-Inverted AlGaAs Quasi-Phase-Matched Devices by GaAs/Ge/GaAs Sublattice Reversal Epitaxy
- Sublattice Reversal in GaAs/Si/GaAs (100) Heterostructures by Molecular Beam Epitaxy
- Methylglyoxal Augments Angiotensin II–Induced Contraction in Rat Isolated Carotid Artery
- ウシ子宮・胎盤マイクロアレイの開発と胎盤における遺伝子発現動態の解析
- ウシ子宮小丘組織の増殖能
- Broad-Band Second-Harmonic Generation in LiNbO_3 Waveguide Using Optimized Domain-Inverted Grating
- Computer-Aided Design of Waveguide Gratings Having Asymmetric Reflectivity Spectra
- Design of Waveguide Grating Based on Simulated Annealing and Narrow-Band Modulation
- Discoordinate Regulation of Expression of Matrix Metalloproteinases and Tissue Inhibitor of Metalloproteinases-3 in Bovine Endometrial Stromal Cells on Type-I Collagen Gel
- An Antiprogesterone, Onapristone, Enhances the Gene Expression of Promatrix Metatloproteinase 3/Prostromelysin-1 in the Uterine Cervix of Pregnant Rabbit
- 細胞非接着性培養プレートによるウシ子宮内膜間質細胞のスフェロイド作製
- 時間分解蛍光免疫測定によるニホンジカ血漿プロジェステロン濃度の直接測定法
- Effect of Lattice Mismatch on the Solidus Compositions of Ga_xIn_P Liquid Phase Epitaxial Crystals
- Orientation Dependence of LPE Growth Behavior of Ga_xIn_P on (100) and (111)B GaAs Substrates
- Growth Mechanism in the Metalorganic Vapor Phase Epitaxy of Metastable GaP_N_x Alloys: A Growth Interruption Study
- Metalorganic Vapor Phase Epitaxy Growth of High Quality Cubic GaN on GaAs (100) Substrates
- High Quality Cubic GaN Growth on GaAs (100) Substrates by Metalorganic Vapor Phase Epitaxy
- Crystal Structure of GaN Grown on 3C-SiC Substrates by Metalorganic Vapor Phase Epitaxy
- Effect of Intrauterine Infusion of Polyvinyl Pyrolidone Iodine on Early Return of Reproductive Function in Postpartum Dairy Cows
- Development of Follicle and Intrafollicular Inhibin-Like Substance in Cows and Sows
- 犬エンドセリン-3前駆体タンパク質の全長cDNAクローニングと臓器発現(短報)(毒性学)
- 犬エンドセリン-3前駆体タンパク質の全長cDNAのクローニングと臓器発現(短報)
- ドキソルビシン慢性投与ラットの心室におけるβ_1アドレナリン受容体及びGTP結合蛋白質の遺伝子発現の変化(短報)(薬理学)
- ウシ黄体期GnRH投与後の黄体形成ホルモン並びに卵胞刺激ホルモンの尿中濃度の変化
- 組織切片を利用した新しい細胞培養技術
- イヌの遺伝性乳ガン原因遺伝子 Brca2 の構造と機能
- Second-Harmonic Generation from GaP/AlP Multilayers on GaP(111)Substrates Based on Quasi-Phase Matching for the Fundamental Standing Wave
- New Semiconductor Second-Harmonic Generator Based on Quasi-Phase-Matching for Cavity-Enhanced Fundamental Standing Wave
- Fast Lateral Transport of Excitons in a GaAs/AlGaAs Quantum Well
- ウシの子宮・胎盤機能を調節する特異分子の発現とその機能の解析に関する研究
- Effects of Gonadotropin Administration on Follicular Growth and In Vitro Fertilization in Female Hypogonadal Mice
- 性腺刺激ホルモン放出ホルモン類縁物質を持続投与されたウシにおける,卵胞刺激ホルモン及びウマ絨毛性性腺刺激ホルモン投与後の血中ステロイドホルモン動態(細菌学)
- 胎盤組織培養系におけるウシ胎盤性ラクトジェンの免疫反応性と生物活性
- High-Temperature Metalorganic Vapor Phase Epitaxial Growth of GaAs/AlGaAs Quantum Structures in Tetrahedral-Shaped Recesses on GaAs (111) B Substrates
- Polarization Characteristics of Crescent-Shaped Tensile-Strained GaAsP/AlGaAs Quantum Wire-Like Lasers
- GaAs/AlGaAs Quantum Structures Grown in Tetrahedral-Shaped Recesses on GaAs (111)B Substrates by Metalorganic Vapor Phase Epitaxy
- Polarization Characteristics of Crescent-Shaped Tensile-Strained GaAsP/AlGaAs Quantum Wire Lasers
- GaAs/AlGaAs Quantum Structures Grown in Tetrahedral-Shaped Recesses on GaAs (111)B Substrates by MOVPE
- Metalorganic Vapor Phase Eitaxy Growth Features of AlGaAs in Tetrahedral-Shaped Recesses on GaAs (111)B Substrates ( Quantum Dot Structures)
- Rectangular AlGaAs/AlAs Quantum Wires Using Spontaneous Vertical Quantum Wells
- The in Situ Growth of Lateral Confinement Enhanced Rectangular AlGaAs/AlAs Quantum Wires by Utilizing the Spontaneous Vertical Quantum Wells
- Photoreflectance Study of Interface Roughness in Ge/SiGe Strained-Layer Heterostructures
- Selective Growth of Cubic GaN in Small Areas on Patterned GaAs(100) Substrates by Metalorganic Vapor Phase Epitaxy
- Metal-Organic Vapor Phase Epitaxy Growth and Optical Study of GaAs/GaAs_P_x Strained-Barrier Single Quantum Well Structures
- Quantum Size Effect of Excitonic Band-Edge Luminescence in Strained Si_Ge_x/Si Single Quantum Well Structures Grown by Gas-Source Si Molecular Beam Epitaxy
- 抗マラリア薬アルテミシニンの摘出モルモット心臓標本における抗コリン作用(薬理学)
- Expression of Integrin Subunits Depend on Bovine Endometrial Stromal Cells Cultured In Vitro
- Angiotensin II Enhances Interleukin-1β-Induced MMP-9 Secretion in Adult Rat Cardiac Fibroblasts
- Mechanisms Underlying Pioglitazone-Mediated Relaxation in Isolated Blood Vessel
- Photoreflectance Study of GaAs/GaAsP Strained-Barrier Quantum Well Structures
- Study on Sublattice Reversal in a GaAs/Ge/GaAs(001) Crystal by X-ray Standing Waves
- GaAs/Ge/GaAs Sublattice Reversal Epitaxy on GaAs (100) and (111) Substrates for Nonlinear Optical Devices
- Extended X-Ray-Absorption Fine-Structure Beats : Application to III-V Semiconductors
- An Extended X-Ray-Absorption Fine-Structure Study of Bond Lengths in GaAs_P_x
- Self-Modulation of Light Output from Semiconductor Injection Lasers with Compound Cavities
- Self-Modulated Light Outputs from Pulsed Injection Lasers with Optical Feedback
- Liquid Phase Epitaxy of Miscible and Immiscible GaInPAs Alloys on (100)-Oriented GaP_xAs_ (x=0, 0.2, 0.4) Substrates
- Induction of Heparanase Gene Expression in Ventricular Myocardium of Rats with Isoproterenol-Induced Cardiac Hypertrophy(Pharmacology)
- Diazepam Increases Calcium Sensitivity of the Skinned Cardiac Muscle Fiber in Guinea Pig
- Effect of eCG Administration on the Reproductive Function in Hypogonadal (hpg) Male Mice
- Generation and Characterization of Anti-Leptin Antisera against Synthetic Peptides and Recombinant Protein
- DYNAMICS OF IMPLANTATION AND PLACENTAL FORMATION IN THE BONIVE : ROLE OF THE BINUCLEATE CELL
- Impaired Gene Expression of β_1-Adrenergic Receptor, but Not Stimulatory G-Protein Gsα, in Rat Ventricular Myocardium Treated with Isoproterenol(Pharmacology)
- Anti-muscarinic action of mitoxantrone in isolated heart muscles (CIRCULATORY SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Optical Properties of Excitons in Semiconductor Quantum Wells
- Oscillator Strength of Excitons in InGaAs/GaAs Quantum Wells
- Nonlinear Optical Coefficient of AlAs Thin Film on GaAs Substrate
- Absolute Measurement of Second-Order Nonlinear Optical Coefficient of LiNbO_3 by Parametric Processes
- Lateral Far-Field Interference Pattern of Buried Heterostructure Lasers
- Output Power Change Associated with Longitudinal Mode Jumping in Semiconductor Injection Lasers
- Plasma and Fecal Sex Steroid Hormone Profiles During the Estrous Cycle in a Japanese Serow (Capricornis crispus)
- Injection-Current-Controlled Bistable Optical Switching in Semiconductor Laser Amplifiers
- Studies on the Reproductive Phenomena in the Post-partum Rat II. Ovulating Hormone Release in the Post-partum Ovulation in Rat
- Studies on the Reproductive Phenomena in the Post-Partum Rat I. Time of Delivery and Post-Partum Ovulation in Rat
- Doxycycline Attenuates Isoproterenol-Induced Myocardial Fibrosis and Matrix Metalloproteinase Activity in Rats
- Biology of the prolactin family in bovine placenta : II. Bovine prolactin-related proteins : Their expression, structure and proposed roles
- Vaspin Can Not Inhibit TNF-α-Induced Inflammation of Human Umbilical Vein Endothelial Cells
- Fecal Progesterone Analysis by Time-Resolved Fluoroimmunoassay (TR-FIA) for Monitoring of Luteal Function in the Sika Doe (Cervus nippon centralis)
- Hormonal Differences in Peripheral Blood and Gene Profiling in the Liver and Lymphocytes in Japanese Black Cattle with Growth Retardation
- Analysis of Uteroplacental-specific Molecules and Their Functions During Implantation and Placentation in the Bovine
- Dynamics of CD3+ T-cell Distribution throughout the Estrous Cycle and Gestation in the Bovine Endometrium
- Matrix-Metalloproteinases-2 and -9 Production in Bovine Endometrial Cell Culture.
- Tonic Block of the Sodium and Calcium Currents by Ketamine in Isolated Guinea Pig Ventricular Myocytes.