Analysis of Uteroplacental-specific Molecules and Their Functions During Implantation and Placentation in the Bovine
スポンサーリンク
概要
- 論文の詳細を見る
In cattle, the mechanisms underlying implantation and placental development are still unclear. Synepitheliochorial placentation in cattle is noninvasive, and thus generates limited interest in terms of degradation and remodeling of endometrial tissues. The overall purpose of this study was three-fold: (1) to examine the gene circuitry around the implantation window, (2) to understand development of the placenta during the peri-implantation period by using a uteroplacental cDNA microarray, and (3) to study the roles of molecules involved in endometrial remodeling. Bovine trophoblastic binucleate cell-specific molecules, such as pregnancy-associated glycoproteins (PAGs), placental lactogen (PL), and prolactin-related proteins (PRPs), were markedly expressed in binucleate cells (BNCs) around implantation. The expression of PRP-1 was specific to the caruncular (CAR) area of the gravid uterine horn. Gelatinases (MMP-2 and -9) in association with heparanase may be central to endometrial remodeling. In situ hybridization analyses of PAGs, PRPs, PL, and heparanase suggested that BNCs expressed these molecules simultaneously. Future studies will further investigate the specific roles of these molecules in placentogenesis. The uteroplacental cDNA microarray presented cascades of molecular signatures not only for the endometrium but also for the intricate dialogue at the level of the feto-maternal interface in cattle. Placentome morphogenesis potentially parallels the dynamic multigenic circuitry and regulates the cell cycle in the endometrium. The roles of BNCs and their secreted molecules remain an enigma, particularly with regard to the adhesion process and endometrial remodeling, which is the focus of this study.<br>
- 日本繁殖生物学会の論文
- 2007-02-01
著者
-
橋爪 一善
岩手大学農学部獣医生理学
-
橋爪 一善
岐阜大学大学院連合獣医学研究科:岩手大学農学部獣医学科基礎獣医学講座
-
橋爪 一善
独立行政法人農業生物資源研究所発生分化研究グループ生殖再生研究チーム
-
Hashizume K
National Inst. Animal Ind. Ibaraki
-
Hashizume Kazuyoshi
Laboratory Of Animal Reproduction Faculty Of Agriculture Tohoku University
-
Hashizume Kazuyoshi
Laboratory Of Veterinary Physiology Department Of Veterinary Medicine Iwate University
-
Hashizume Kazuyoshi
Laboratory Of Veterinary Physiology Department Of Veterinary Medicine Faculty Of Agriculture Iwate U
-
Hashizume Kazuyoshi
Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Iwate University
関連論文
- ウシ妊娠期の大型黄体細胞における暗調顆粒の超微形態学的特性とリラキシン免疫局在
- クローンウシ胎仔における Leptin 遺伝子、POU5F1遺伝子CpGアイランドのエピジェネティック状況の解析
- クローン牛胎児の組織、およびドナー細胞のDNAメチル化プロフィール
- 細胞非接着性培養プレートによるウシ子宮内膜間質細胞のスフェロイド作製
- 時間分解蛍光免疫測定法による牛の血漿中エストラジオール17β濃度の直接判定(臨床繁殖学)
- 時間分解蛍光免疫測定法によるニホンジカ糞中プロジェステロン測定(臨床繁殖学)
- ウシ子宮内膜培養細胞におけるマトリックスメタロプロテナーゼ2および9の産生
- 子宮内膜および栄養膜細胞におけるEMMPRINの発現とその分子機能解析
- B26 コラーゲンゲルによるウシ子宮内膜間質細胞の3次元培養におけるMMPsおよびTIMPs発現調節
- 表皮角化細胞での恒常的なMAILの発現におけるNF-κBの役割(生化学)
- イヌBRCA2遺伝子座のエキソン27領域に存在する遺伝的多型の解析(生化学)
- ウシ子宮内膜培養細胞におけるマトリックスメタロプロテナーゼ2および9の産生
- 着床に伴うウシ子宮内膜細胞外マトリックスの特異的動態
- ウシ子宮・胎盤マイクロアレイの開発と胎盤における遺伝子発現動態の解析
- ウシ子宮小丘組織の増殖能
- Discoordinate Regulation of Expression of Matrix Metalloproteinases and Tissue Inhibitor of Metalloproteinases-3 in Bovine Endometrial Stromal Cells on Type-I Collagen Gel
- An Antiprogesterone, Onapristone, Enhances the Gene Expression of Promatrix Metatloproteinase 3/Prostromelysin-1 in the Uterine Cervix of Pregnant Rabbit
- 細胞非接着性培養プレートによるウシ子宮内膜間質細胞のスフェロイド作製
- 時間分解蛍光免疫測定によるニホンジカ血漿プロジェステロン濃度の直接測定法
- Effect of Intrauterine Infusion of Polyvinyl Pyrolidone Iodine on Early Return of Reproductive Function in Postpartum Dairy Cows
- Development of Follicle and Intrafollicular Inhibin-Like Substance in Cows and Sows
- ウシ黄体期GnRH投与後の黄体形成ホルモン並びに卵胞刺激ホルモンの尿中濃度の変化
- 組織切片を利用した新しい細胞培養技術
- イヌの遺伝性乳ガン原因遺伝子 Brca2 の構造と機能
- ウシの子宮・胎盤機能を調節する特異分子の発現とその機能の解析に関する研究
- Effects of Gonadotropin Administration on Follicular Growth and In Vitro Fertilization in Female Hypogonadal Mice
- 性腺刺激ホルモン放出ホルモン類縁物質を持続投与されたウシにおける,卵胞刺激ホルモン及びウマ絨毛性性腺刺激ホルモン投与後の血中ステロイドホルモン動態(細菌学)
- 胎盤組織培養系におけるウシ胎盤性ラクトジェンの免疫反応性と生物活性
- Expression of Integrin Subunits Depend on Bovine Endometrial Stromal Cells Cultured In Vitro
- Induction of Heparanase Gene Expression in Ventricular Myocardium of Rats with Isoproterenol-Induced Cardiac Hypertrophy(Pharmacology)
- Effect of eCG Administration on the Reproductive Function in Hypogonadal (hpg) Male Mice
- Generation and Characterization of Anti-Leptin Antisera against Synthetic Peptides and Recombinant Protein
- DYNAMICS OF IMPLANTATION AND PLACENTAL FORMATION IN THE BONIVE : ROLE OF THE BINUCLEATE CELL
- Plasma and Fecal Sex Steroid Hormone Profiles During the Estrous Cycle in a Japanese Serow (Capricornis crispus)
- Studies on the Reproductive Phenomena in the Post-partum Rat II. Ovulating Hormone Release in the Post-partum Ovulation in Rat
- Studies on the Reproductive Phenomena in the Post-Partum Rat I. Time of Delivery and Post-Partum Ovulation in Rat
- Biology of the prolactin family in bovine placenta : II. Bovine prolactin-related proteins : Their expression, structure and proposed roles
- Fecal Progesterone Analysis by Time-Resolved Fluoroimmunoassay (TR-FIA) for Monitoring of Luteal Function in the Sika Doe (Cervus nippon centralis)
- Hormonal Differences in Peripheral Blood and Gene Profiling in the Liver and Lymphocytes in Japanese Black Cattle with Growth Retardation
- Analysis of Uteroplacental-specific Molecules and Their Functions During Implantation and Placentation in the Bovine
- Dynamics of CD3+ T-cell Distribution throughout the Estrous Cycle and Gestation in the Bovine Endometrium
- Matrix-Metalloproteinases-2 and -9 Production in Bovine Endometrial Cell Culture.