Synthesis of N-[2-(2,4-Difluorophenoxy)trifluoromethyl-3-pyridyl]sulfonamides and Their Inhibitory Activities against Secretory Phospholipase A2
スポンサーリンク
概要
- 論文の詳細を見る
N-[2-(2,4-Difluorophenoxy)trifluoromethyl-3-pyridyl]sulfonamide derivatives 3—6 were prepared by the reaction of 3-pyridylamines and sulfonyl chlorides. Inhibitory activities of these compounds toward secretory phospholipase A2 (sPLA2) were examined and N-[2-(2,4-difluorophenoxy)-5-trifluoromethyl-3-pyridyl]-2-naphthalenesulfonamide (5c) was found to be the most potent against sPLA2 with an IC50 value of 90 μM.
- 公益社団法人 日本薬学会の論文
著者
-
Ishihara Keiichi
Department Of Biochemistry Kyoto Pharmaceutical University
-
Akiba Satoshi
Department Of Pathological Biochemistry Kyoto Pharmaceutical University
-
Nakayama H
Laboratory Of Biofunctional Chemistry Faculty Of Pharmaceutical Sciences Kumamoto University
-
Nakayama Hitoshi
Department Of Agricultural Chemistry College Of Agriculture University Of Osaka Prefecture
-
Akiba Satoshi
Dep. Of Pathological Biochemistry Kyoto Pharmaceutical Univ.
-
Ishihara Keiichi
Dep. Of Pathological Biochemistry Kyoto Pharmaceutical Univ.
-
Uenishi Junichi
Department Of Chemistry Faculty Of Science Okayama University Of Science
関連論文
- Olmesartan Inhibits Angiotensin II–Induced Migration of Vascular Smooth Muscle Cells Through Src and Mitogen-Activated Protein Kinase Pathways
- Group IVA Phospholipase A_2-Associated Production of MMP-9 in Macrophages and Formation of Atherosclerotic Lesions(Highlighted paper selected By Editor-in-chief,Biochemistry)
- Inhibition of Cytosolic Phospholipase A_2 Suppresses Production of Cholesteryl Ester through the Reesterification of Free Cholesterol but not Formation of Foam Cells in Oxidized LDL-Stimulated Macrophages(Highlighted paper selected by Editor-in-chief,Bioc
- Calculation of Structure Factor for Three-Dimenisional Penrose Tilting
- Hsp105α Enhances Stress-Induced Apoptosis but Not Necrosis in Mouse Embryonal F9 cells
- Triacylglycerol Deposition with Group IVC Phospholipase A2 Expression in Oleate- and Linoleate-Stimulated Huh-7 Hepatocytes
- Role of Phospholipase D-Derived Phosphatidic Acid as a Substrate for Phospholipase A_2 in RBL-2H3 Cells
- Involvement of Lipoxygenase Pathway in Docosapentaenoic Acid-Induced Inhibition of Platelet Aggregation
- Ceramide Enhances Susceptibility of Membrane Phospholipids to Phospholipase A_2 through Modification of Lipid Organization in Platelet Membranes
- Stimulation by Ceramide of Phospholipase A_2 Activation through a Mechanism Related to the Phospholipase C-Initiated Signaling Pathway in Rabbit Platelets
- High Glucose-Induced Cytosolic Phospholipase A_2 Activation Responsible for Eicosanoid Production in Rat Mesangial Cells
- Lipid Peroxide Overcomes the Inability of Platelet Secretory Phospholipase A_2 to Hydrolyze Membrane Phospholipids in Rabbit Platelets
- Stimulation of Platelet-Activating Factor Synthesis in Polymorphonuclear Leukocytes from Streptozotocin-Induced Diabetic Rats
- Usefulness of ^TlCl/^I-BMIPP dual-myocardial SPECT for patients with non-ST segment elevation myocardial infarction
- Nicotine Suppresses Tunicamycin-Induced, But Not Thapsigargin-Induced, Expression of GRP78 during ER Stress-Mediated Apoptosis in PC12 Cells
- Nanometer-Sized Crystals Formed by the Mechanical Alloying in the Ag-Fe System
- Transformation form Icosahedral Quasicrystalline to Amorphous Structure in Al_Cu_Fe_
- DNA vaccination of HSP105 leads to tumor rejection of colorectal cancer and melanoma in mice through activation of both CD4^+ T cells and CD8^+ T cells
- Growth of Low-Resistivity n-Type ZnTe by Metalorganic Vapor Phase Epitaxy
- Dependence of Hydrolysis of β-Lactams with a Zinc(II)-β-Lactamase Produced from Sermtia marcescens (IMP-1) on pH and Concentration of Zinc(II) Ion : Dissociation of Zn(II) from IMP-1 in Acidic Medium
- Requirement of Calcium Influx for Hydrolytic Action o fMembrane Phospholipids by Cytosolic Phospholipase A Rather than Mitogen-Activated Protein Kinase Activation in FcεRI-stimulated Rat Peritoneal Mast Cells
- Importance of the Phospholipase D-Initiated Sequential Pathway for Arachidonic Acid Release and Prostaglandin D_2 Genration by Rat Peritoneal Mast Cells
- Advanced Glycation End Products (AGE) Inhibit Scavenger Receptor Class B type I-Mediated Reverse Cholesterol Transport : a New Crossroad of AGE to Cholesterol Metabolism
- Immunocytochemical localization of nicotinic acetylcholine receptor in the rat cerebellar cortex
- EFFECTS OF ESTRADIOL ON DIFFERENTIATION OF REPRODUCTIVE ORGANS AND DEVELOPMENT OF THE SPINE IN CHICK EMBRYOS
- Ventricular Hemorrhage at an Early Stage of Moyamoya Disease : Case Report
- Big Mitogen-Activated Protein Kinase 1 Protects Cultured Rat Aortic Smooth Muscle Cells From Oxidative Damage
- Glutamine synthesis in gelminating castor bean endosperm
- Subcellular localization of glycolytic key enzymes in germinating castor bean endosperm
- Partial purification and some regulatory properties of pyruvate kinase from germinating castor bean endosperm
- Stoichiometry and Binding Site Analysis of Ligand-Human Serum Albumin Complex by Photoaffinity Labeling and Mass Spectrometry
- VEGF-Enhanced Proliferation under Hypoxia by an Autocrine Mechanism in Human Vascular Smooth Muscle Cells
- Cellular Function of Calcium-Independent Phospholipase A_2(Diversity of Phospholipase A_2 Enzymes)
- Oral Administration of Synthetic Retinoid Am80 (Tamibarotene) Decreases Brain β-Amyloid Peptides in APP23 Mice
- Synthesis of N-(Trifluoromethyl-2-pyridinyl)arenesulfonamides as an Inhibitor of Secretory Phospholipase A2
- Olmesartan Inhibits Angiotensin II-Induced Migration of Vascular Smooth Muscle Cells Through Src and Mitogen-Activated Protein Kinase Pathways
- STUDIES ON ALTERNATION OF NICOTINE METABOLIZING ENZYME ACTIVITIES IN VARIOUS SPECIES. (8) : EFFECT OF ADMINISTRATION ROUTE ON RAT
- Efficient Transport of Aliphatic Amino Acids Mediated by Lanthanide Complex Carriers under Neutral Conditions
- EFFECTS OF MELATONIN AND 5-METHOXYTRYPTAMINE UNDER EXCESSIVE ILLUMINATION IN CYANOBACTERIUM
- Suppression of Oxidized LDL-Induced PDGF Receptor β Activation by Ginkgo Biloba Extract Reduces MMP-1 Production in Coronary Smooth Muscle Cells
- Synthesis of N-[2-(2,4-Difluorophenoxy)trifluoromethyl-3-pyridyl]sulfonamides and Their Inhibitory Activities against Secretory Phospholipase A2
- Big Mitogen-Activated Protein Kinase 1 Protects Cultured Rat Aortic Smooth Muscle Cells From Oxidative Damage
- Evaluation of primary prostate cancer using ^C-methionine-PET/CT and ^F-FDG-PET/CT
- Clinical and microbiological evaluation of hemodialysis-associated pneumonia (HDAP) : should HDAP be included in healthcare-associated pneumonia?
- Effect of a peroxynitrite scavenger, a manganese-porphyrin compound on airway remodeling in a murine asthma
- A cross-coupling reaction of methylsulfinylarene.