Synthesis of N-(Trifluoromethyl-2-pyridinyl)arenesulfonamides as an Inhibitor of Secretory Phospholipase A2
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概要
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A series of N-(trifluoromethyl-2-pyridinyl)alkane- and arenesulfonamides 2—5 have been synthesized by the substitution reaction of 2-chloro(trifluoromethyl)pyridines 6 with alkane- and arenesulfonamides 7. Their inhibitory activities against secretory phospholipase A2 of porcine pancreas were examined and the analog N-[4,5-bis(trifluoromethyl)-2-pyridinyl]-4-trifluoromethylbenzenesulfonamide 4i was shown to have the highest inhibitory activity, with an IC50 value of 0.58 mM.
- 公益社団法人 日本薬学会の論文
著者
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AKIBA Satoshi
Department of Pathological Biochemistry, Kyoto Pharmaceutical University
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Ishihara Keiichi
Department Of Biochemistry Kyoto Pharmaceutical University
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Akiba Satoshi
Department Of Pathological Biochemistry Kyoto Pharmaceutical University
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Nakayama H
Laboratory Of Biofunctional Chemistry Faculty Of Pharmaceutical Sciences Kumamoto University
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Nakayama Hitoshi
Department Of Agricultural Chemistry College Of Agriculture University Of Osaka Prefecture
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MORITA Yuka
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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Kimura Hirohiko
Ishihara Sangyo Kaisha, Ltd.
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Uenishi Junichi
Department of Pharmaceutical Chemistry, Kyoto Pharmaceutical University
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Uenishi Junichi
Department Of Chemistry Faculty Of Science Okayama University Of Science
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Morita Yuka
Department Of Otorhinolaryngology Graduate School Of Medical And Dental Sciences Niigata University
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Uenishi Jun'ichi
Department of Pharmaceutical Chemistry, Kyoto Pharmaceutical University
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Nakayama Hitoshi
Department of Pharmaceutical Chemistry, Kyoto Pharmaceutical University
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Morita Yuka
Department of Pharmaceutical Chemistry, Kyoto Pharmaceutical University
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