Bcl11bヘテロ遺伝子型はマウスに加齢性難聴と蝸牛外有毛細胞の変性をもたらす

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概要

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• BCL11B/CTIP2 zinc-finger transcription factor is expressed in various types of cells in many different tissues. This study showed that BCL11B is expressed in the nucleus of the outer hair cells of the mouse cochlea, degeneration of which is known to cause deafness and presbycusis or age-related hearing loss (AHL). We tested whether or not Bcl11b heterozygosity would affect AHL in mice. Analysis of auditory brainstem responses revealed AHL in Bcl11b+/– heterozygous, but not wild-type, mice, which was evident as early as 3 months after birth. Histological abnormalities were observed in the outer hair cells of the Bcl11b +/– mice at 6 months of age with hearing loss. These results suggest that the AHL observed in Bcl11b+/– mice is the result of impairment of the outer hair cells and that BCL11B activity is required for the maintenance of outer hair cells and normal hearing.

• 2011-07-01

著者

• Kominami Ryo

  Department Of Molecular Genetics Graduate School Of Medical And Dental Sciences Niigata University

• Kominami Ryo

  Department Of Biochemistry Faculty Of Medicine Niigata University

• Mishima Yukio

  Department Of Molecular Genetics Graduate School Of Medical And Dental Sciences Niigata University

• Nomura Tomoyuki

  Department Of Internal Medicine And Bioregulation

• Takahashi Sugata

  Department Of Otolaryngology Niigata University Graduate School Of Medical And Dental Sciences

• OKUMURA Hitoshi

  Department of Molecular Genetics, Graduate School of Medical and Dental Sciences, Niigata University

• MIYASAKA Yuki

  Department of Molecular Genetics, Graduate School of Medical and Dental Sciences, Niigata University

• Takahashi Sugata

  Department Of Otorhinolaryngology Graduate School Of Medical And Dental Sciences Niigata University

• Morita Yuka

  Department Of Otorhinolaryngology Graduate School Of Medical And Dental Sciences Niigata University

• Miyasaka Yuki

  Department Of Molecular Genetics Graduate School Of Medical And Dental Sciences Niigata University

• Okumura Hitoshi

  Department Of Molecular Genetics Graduate School Of Medical And Dental Sciences Niigata University

• Nomura Tomoyuki

  Department Of Otorhinolaryngology Graduate School Of Medical And Dental Sciences Niigata University

• 奥村 仁

  Department of Molecular Genetics, Graduate School of Medical and Dental Sciences, Niigata University

• 宮坂 勇輝

  Department of Molecular Genetics, Graduate School of Medical and Dental Sciences, Niigata University

• 森田 由香

  Department of Otorhinolaryngology, Graduate School of Medical and Dental Sciences, Niigata University

• MISHIMA Yukio

  Department of Biochemistry, Cancer Institute , Japanese Foundation for Cancer Research

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