Role of the transcription factor Bcl11b in development and lymphomagenesis

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概要

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• Bcl11b is a lineage-specific transcription factor expressed in various cell types and its expression is important for development of T cells, neurons and others. On the other hand, Bcl11b is a haploinsufficient tumor suppressor and loss of a Bcl11b allele provides susceptibility to mouse thymic lymphoma and human T-cell acute lymphoblastic leukemia. Although there are many transcription factors affecting both cell differentiation and cancer development, Bcl11b has several unique properties. This review describes phenotypes given by loss of Bcl11b and roles of Bcl11b in cell proliferation, differentiation and apoptosis, taking tissue development and lymphomagenesis into consideration.<BR><BR>(Communicated by Shigekazu NAGATA, M.J.A.)

著者

• Kominami Ryo

  Department Of Biochemistry Faculty Of Medicine Niigata University

• KOMINAMI Ryo

  Department of Molecular Genetics, Niigata University Graduate School of Medical and Dental Sciences

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• マウス仁形成体部位の銀染色性の補償的変化〔英文〕
• Radiation carcinogenesis in mouse thymic lymphomas
• Bcl11bヘテロ遺伝子型はマウスに加齢性難聴と蝸牛外有毛細胞の変性をもたらす
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