マウス仁形成体部位の銀染色性の補償的変化〔英文〕

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概要

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• Silver-stainability of nucleolar organizer regions (NORs) that contain genes for ribosomal RNA (rDNA) was investigated using two mouse strains, BALB/cCrSlc and MOA, and their hybrid progeny. The patterns of segregation of the rDNA clusters were analyzed in terms of chromosomal C-banding and by use of a polymorphic probe for the variable region in backcrossed N2 and N3 individuals. The results indicate that the intensity of Ag-NOR staining is stably inherited in most of the rDNA clusters, irrespective of different genetic backgrounds. In some clusters, such as those on chromosome 12 of BALB/cCrSlc, a modulation of the intensity is observed. This modulation seems to be due to compensatory activation via a change in the number of actively transcribed genes. The change from silver-negative to silver-positive staining of the NOR of chromosome 12 of BALB/cCrSlc was correlated with demethylation of the genes.

• 日本遺伝学会の論文
• 1992-06-25

著者

• 鈴木 仁

  東京慈恵会医科大学

• 森脇 和郎

  理化学研究所バイオリソースセンター

• Kominami Ryo

  Department Of Biochemistry Faculty Of Medicine Niigata University

• 森脇 和郎

  総合研究大学院大学

• Moriwaki Kazuo

  National Institute Of Genetics

• Moriwaki Kazuo

  Natl. Inst. Genetics

• Moriwaki Kazuo

  Bio Resource Centre Riken Tsukuba Institute

• Moriwaki Kazuo

  Department Of Cell Genetics National Institute Of Genetics

• Suzuki Hitoshi

  Division of Bioscience, Graduate School of Environmental Earth Science, Hokkaido University

• Nishimura Masahiko

  Institute For Experimental Animals Hamamatsu University School Of Medicine

• Sakurai Susumu

  Division Of Molecular Genetics Kohno Clinical Medicine Research Institute

• 森脇 和郎

  国立遺伝研

• Sakurai Susumu

  Division Of Molecular Genetics Institute Of Medical Science Jikei University School Of Medicine

• Nishimura Masahiko

  Institute Of Experimental Animals Hamamatsu University School Of Medicine

• Suzuki Hitoshi

  Division Of Bioscience Graduate School Of Environmental Earth Science Hokkaido University

• 鈴木 仁

  Division of Bioscience, Graduate School of Environmental Earth Science, Hokkaido University

• MORIWAKI Kazuo

  Department of Cell Genetics

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