Xanthine Oxidase-Derived Reactive Oxygen Species Activate Nuclear Factor Kappa B During Hepatic Ischemia in Rats
スポンサーリンク
概要
- 論文の詳細を見る
The present study was carried out to elucidate the relationship between the generation of reactive oxygen species (ROS) and an activation of nuclear factor (NF) kappa B in a hepatic ischemia-reperfusion model. During the ischemic period, the contents of xanthine oxidase (XOD) metabolites and thiobarbituric acid-reactive substances were significantly increased, and NF-kappa B was activated in the liver of rats. The activation of NF-kappa B was inhibited by pretreatment of allopurinol (10-100mg/kg, i.p.) in a dose-dependent manner. In conclusion, this suggests that the XOD-derived ROS may activate NF-kappa B during ischemia.
- 社団法人 日本薬理学会の論文
- 2000-11-01
著者
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Akagi Masaaki
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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MATSUI Nobuaki
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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FUKUISHI Nobuyuki
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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KASAJIMA Kazumi
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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Akagi Masaaki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Matsui Nobuaki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Kadota Kazue
Dep. Of Pharmacology Fac. Of Pharmaceutical Sciences Tokushima Bunri Univ.
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INAIZUMI Keiichi
Department of Clinical Pharmaceutical Science, Graduate School of Natural Science and Technology, Ok
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SATSUKI Ikuko
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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MORITA Yuka
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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KANOH Reiko
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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Kanoh Reiko
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Satsuki Ikuko
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Matsui Nobuaki
Department Of Gastroenterological And General Surgery Showa University School Of Medicine
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Kasajima Kazumi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Inaizumi Keiichi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Morita Y
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Morita Yuka
Department Of Otorhinolaryngology Graduate School Of Medical And Dental Sciences Niigata University
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