NOVEL ACTION OF QUINOLONES ON OSTEOCLAST-LIKE CELLS
スポンサーリンク
概要
- 論文の詳細を見る
Quinolones have a broad antibacterial spectrum against Gram-negative and Gram-positive bacteria. The compounds, however, have a few adverse effects, such as convulsion and toxicity to articular cartilage. We observed that some quinolones such as Naldixic acid, Ofloxacin, and Norfloxacin have osteoclast-inducing effects. All quinolones we tested produced tumor necrosis factor-alpha and prostaglandin E_2, and have potency as osteoclast inducers to cultured cells. These results suggest that some quinolones affect osteoclast induction or activation, and this may be related to the production of tumor necrosis factor-alpha (TNF-alpha) and prostaglandin E_2 (PGE_2).
- 日本トキシコロジー学会の論文
- 1999-12-20
著者
-
Akagi Masaaki
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
-
MATSUI Nobuaki
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
-
MATSUI Nobuaki
Faculty of Pharmaceutical Sciences, Tokushima Bunri University
-
FUKUISHI Nobuyuki
Faculty of Pharmaceutical Sciences, Tokushima Bunri University
-
AKAGI Masaaki
Faculty of Pharmaceutical Sciences, Tokushima Bunri University
-
Akagi Masaaki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Tokushima Bunri University
-
Akagi Masaaki
Faculty Of Pharmaceutical Sciences Okayama University
-
Matsui Nobuaki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Tokushima Bunri University
-
KANOH Reiko
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
-
Kanoh Reiko
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Tokushima Bunri University
-
KANOH Reiko
Faculty of Pharmaceutical Sciences. Tokushima Bunri University
関連論文
- Participation of Prostaglandin E2 Receptor in Nasal Congestion of Brown Norway Rats
- Interaction between Hippocampal γ-Aminobutyric AcidA and N-Methyl-D-aspartate Receptors in the Retention of Spatial Working Memory in Rats
- Upregulation of Heme Oxygenase-1 by Degranulation in Rat Basophilic Leukemia Cells(Molecular and Cell Biology)
- The Protective Effect of H_2-Receptor Activation Against the Duration of Myocardial Hypoxia/Reoxygenation-Induced Ventricular Fibrillation in Sensitized Guinea-Pig Hearts
- Enzymatic Measurement of Tryptase-Like Protease Release from Isolated Perfused Guinea Pig Heart during Ischemia-Reperfusion(Pharmacology)
- Neurotrophic Effect of Magnolol in the Hippocampal CA1 Region of Senescence-Accelerated Mice (SAMP1)(Pharmacology)
- INHIBITON OF NF-κB ACTIVATION DURING ISCHEMIA REDUCES HEPATIC ISCHEMIA/REPERFUSION INJURY IN RATS
- The Protective Effect of H2-Receptor Activation Against the Duration of Myocardial Hypoxia/Reoxygenation-Induced Ventricular Fibrillation in Sensitized Guinea-Pig Hearts
- P7-03 The effect of cadmium on FcεR-dependent degranulation from RBL-2H3 cells(IMMUNE AND ALLERGIC SYSTEM/KIDNEYS AND URINARY EXCRETION SYSTEM/CYTOTOXICITY/OTHERS-1)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- Inhibitory Effect of Olopatadine on Antigen-Induced Eosinophil Infiltration and the LFA-1 and Mac-1 Expression in Eosinophils
- Synthesis of Oligosaccharides of Genistein and Quercetin as Potential Anti-inflammatory Agents
- Synthesis of α-Tocopheryl Disaccharides as Potential Antiallergic Agents
- Health-related quality of life in patients with advanced colorectal cancer : results from a phase II study of S-1 combined with irinotecan (CPT-11)
- Mast Cells Modulate Interleukin-4 Production Independently of Interferon-gamma Generation by Invariant Natural Killer T Cells through the Suppression of Notch Signaling
- Anti-allergic Effect of Tea-Leaf Saponin (TLS) from Tea Leaves (Camellia sinensis var. sinensis)
- Xanthine Oxidase-Derived Reactive Oxygen Species Activate Nuclear Factor Kappa B During Hepatic Ischemia in Rats
- Human Cathelicidin CAP18/LL-37 Changes Mast Cell Function toward Innate Immunity(Molecular and Cell Biology)
- Health-related quality of life of colorectal cancer patients receiving oral UFT plus leucovorin compared with those with surgery alone
- NOVEL ACTION OF QUINOLONES ON OSTEOCLAST-LIKE CELLS
- Inhibitory Effect of Epinastine on Superoxide Generation by Rat Neutrophils
- Effects of Anti-dementia Drugs on Morphine-Induced Somnolence
- STUDY ON THE SUBPLASMALEMMAL UNDERCOAT AND CYTO-SKELETON OF THE RAT MAST CELLS