Inhibitory Effect of Epinastine on Superoxide Generation by Rat Neutrophils
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概要
- 論文の詳細を見る
We studied the effects of antiallergic drugs, epinastine, ketotifen, oxatomide, mequitazine and cromolyn sodium on superoxide anion (O<SUB>2</SUB><SUP>-</SUP>) generation from rat neutrophils. Epinastine, ketotifen, oxatomide and mequitazine dose-dependently prevented the <I>N</I>-formyl-Met-Leu-Phe- and phorbol 12-myristate 13-acetate-induced O<SUB>2</SUB> generation, but cromolyn sodium did not prevent it. When membrane and cytosol fractions were incubated with each drug, epinastine, ketotifen and mequitazine prevented O<SUB>2</SUB><SUP>-</SUP> generation. On the other hand, when only the membrane fraction was incubated with each drug, ketotifen and mequitazine prevented O<SUB>2</SUB><SUP>-</SUP> generation, but epinastine did not. Epinastine may inhibit the NADPH oxidase system through the obstruction of NADPH oxidase-associated cytosol components.
- 社団法人 日本薬理学会の論文
- 1995-08-01
著者
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Akagi Reiko
Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural Univer
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Akagi Masaaki
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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FUKUISHI Nobuyuki
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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AKAGI Reiko
Faculty of Health and Welfare Science, Okayama Prefectural University
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Kan T
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Akagi Reiko
Department Of Nutritional Science Faculty Of Health And Welfare Science Okayama Prefectural Universi
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Akagi Masaaki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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KAN Tomoko
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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HIROSE Kimihisa
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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Hirose Kimihisa
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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