Fundamental Role of Heme Oxygenase in the Protection Against Ischemic Acute Renal Failure
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概要
- 論文の詳細を見る
Oxidative stress conditions such as oxidant stimuli, inflammation, exposure to xenobiotics and ionizing irradiation provoke cellular responses, principally involving transcriptional activation of genes encoding proteins that participate in the defense against oxidative tissue injuries. Excess of free heme, which is released from hemeproteins under these conditions, may constitute a major threat because it catalyzes the formation of reactive oxygen species. Exposure of mammalian cells to oxidative stimuli induces heme oxygenase-1 (HO-1), the rate-limiting enzyme in heme degradation, as well as the 32-kDa heat shock protein. In various tissue injury systems, HO-1 induction has been shown to confer protection, while its abrogation has been shown to accelerate cellular injuries. In this review, recent findings concerning the role of HO-1 as a protective response against oxidative stress conditions are summarized, with a particular emphasis on its protective role in ischemic acute renal failure.
- 社団法人 日本薬理学会の論文
- 2002-02-01
著者
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Akagi Reiko
Department Of Nutritional Science Faculty Of Health And Welfare Science Okayama Prefectural Universi
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Sassa Shigeru
Laboratory Of Biochemical Hematology The Rockefeller University
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Takahashi Toru
Department Of Hematology And Gastroenterology Caress Alliance Tenshi Hospital
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Takahashi Toru
Department Of Anesthesiology And Resuscitology Okayama University Medical School
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Takahashi Toru
Department Of Anatomy Gifu University School Of Medicine
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TAKAHASHI Toru
Department of Anesthesiology and Resuscitology, Okayama University Medical School
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