Hemodynamic and Metabolic Effects of Hypertonic Saline Infusion in Normovolemic Dogs

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Aims : The hemodynamic and metabolic effects of hypertonic saline (HTS) infusion were studied in normovolemic dogs. Methods : Seven adult mongrel dogs, weighing 10 to 15kg, were used in this study. Under general anesthesia, the pericardium was opened via a right thoracotomy. High-dosage of HTS (10% NaCl, 5ml/kg) was infused intravenously within a five minute period. Results: Systemic blood pressure significantly increased from 110± 10mmHg to 125± 10mmHg. Central venous pressure and left atrial pressure also significantly increased (4.6± 1.7 → 9.3+ 1.9mmHg, 3.5± 1.4 → 5.7±2.4mmHg, respectively). Cardiac output increased significantly from 2.0±0.2L/min to 3.0±0.2L/min 10 minutes after HTS infusion. Arterial blood gas analysis revealed that pH, base excess and HCO3^- had decreased significantly 10 minutes after HTS infusion. Hemoglobin and hematocrit levels significantly decreased after HTS infusion. Although O_2 content decreased significantly, the myocardial O_2 extraction rate did not change. Serum sodium and chloride values increased significantly and sustained those levels until 60 minutes after HTS infusion. Conclusions: In conclusion, HTS infusion remains a simple and valuable clinical procedure to use in restoring adequate hemodynamic conditions after hypovolemic shock.
北関東医学会の論文
2004-05-01