Anti-allergic Effect of Tea-Leaf Saponin (TLS) from Tea Leaves (Camellia sinensis var. sinensis)
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概要
- 論文の詳細を見る
We investigated the anti-allergic effect of tea-leaf saponin (TLS), which was a mixture of saponins separated from the leaves of Camellia sinensis var. sinensis, in guinea pigs and rats. TLS (20-100 mg/kg) dose-dependently inhibited experimentally-induced asthma, and ID_<50> was 61.7 mg/kg. TLS (20-100 mg/kg) dose-dependently inhibited a 48 h homologous PCA (passive cutaneous anaphylaxis) reaction, and the inhibitory effect was similar to that of tranilast. TLS (1-100 μg/ml) also inhibited the release of antigen-induced leukotriene (LT) C_4 from sensitized guinea pig lung samples in a dose-dependent fashion, but did not prevent histamine release. TLS (0.01-0.5 μg/ml) inhibited histamine release from rat peritoneal mast cells induced by compound 48/80. At higher concentrations, TLS elicited histamine release. These findings suggest that TLS may be a useful protective agent against clinical allergy, and that the inhibitory effects of TLS on mediator release are in some way related to its inhibitory effect on experimental-induced asthma and PCA reaction.
- 公益社団法人日本薬学会の論文
- 1997-05-15
著者
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SAGESAKA Yuko
Central Research Institute, ITO EN, LTD.
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Sagesaka Yuko
Central Research Institute Ito En Ltd.
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Sagesaka Yuko
Central Research Institute Ito-enco. Ltd.
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Akagi Reiko
Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural Univer
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Akagi Masaaki
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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FUKUISHI Nobuyuki
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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AKAGI Reiko
Faculty of Health and Welfare Science, Okayama Prefectural University
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Kan T
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Akagi Reiko
Department Of Nutritional Science Faculty Of Health And Welfare Science Okayama Prefectural Universi
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Akagi Masaaki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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KAN Tomoko
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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SAGESAKA Yuko
Central Research Institute
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