Tea Catechins with a Galloyl Moiety Reduce Body Weight and Fat
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概要
- 論文の詳細を見る
We investigated the effect of consumption of a catechin-containing drink on body fat level and its safety in healthy adults. The beverage (250 ml/bottle) contained 215.3 mg of tea catechins mostly possessing a galloyl moiety, which included (-)-epigallocatechin gallate 74.6 mg, (-)-epicatechin gallate 34.1 mg, (-)-gallocatechin gallate 77.8 mg, (-)-catechin gallate 24.5 mg. We conducted a double-blind study with three parallel groups. Healthy subjects (98 men and 97 women) aged from 20 to 65 years old with 22.5<body mass index (BMI)≤30 kg/m^2 were assigned to consume 3 bottles of placebo drink (control group), 2 bottles of catechin-containing drink and 1 bottle of placebo drink (low-dose group), or 3 bottles of catechin-containing drink (high-dose group), per day at mealtimes for 12 week (daily consumption of catechins was 41.1, 444.3 or 665.9 mg respectively). Compared to the value at 0 week, consumption of two or three bottles of catechin-containing drink results in significant decrease in body weight and BMI at 8 and 12 or 4, 8 and 12 week, respectively. Body weight and BMI was significantly decreased in both catechin groups compared with the control group from 4 to 12 week. The measurements of abdominal fat areas indicated significant reduction of total fat area and visceral fat area in both catechin groups compared with the control group at 12 week. Thus our present observations suggest that consumption of a catechin-containing drink may be useful for the prevention of obesity-related disorders.
- 社団法人日本薬学会の論文
- 2005-04-01
著者
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KAJIMOTO Yoshitaka
Department of Internal Medicine and Molecular Therapeutics
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Kajimoto Osami
味の素食品研究所
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SAGESAKA Yuko
Central Research Institute, ITO EN, LTD.
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Sagesaka Yuko
Central Research Institute Ito En Ltd.
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SUZUKI Yuko
Central Research Institute, Ito En, Ltd.
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KAKUDA Takami
Central Research Institute, Ito En, Ltd.
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Nagata Kozo
大阪外語大学
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Kajimoto Osami
Osaka Univ. Foreign Studies Osaka Prefecture Jpn
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UNNO Tomonori
Central Research Institute, Itoen Ltd.
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YOSHIKAWA Toshikazu
First Department of Internal Medicine, Kyoto Prefectural University of Medicine
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Suzuki Yuko
Central Research Institute Ito En Ltd.
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Nagata Kozo
Central Research Institute Itoen Ltd.
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Kajimoto Osami
Health Management Center, Osaka University of Foreign Studies
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Yabune Mitsuharu
Department of Clinical Trial and Research, Soiken Inc.
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Nakamura Tadashi
Graduate School of Medical Research Molecular Control Internal Medicine, Osaka University
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Kotani Kazuaki
Graduate School of Medical Research Molecular Control Internal Medicine, Osaka University
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Nozawa Ayumu
Central Research Institute, ITOEN, Ltd.
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Kajimoto Yoshitaka
Soiken Inc. Osaka Prefecture Jpn
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Kajimoto Yoshitaka
Department Of Clinical Trial And Research Soiken Inc.
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Unno T
Department Of Home Economics Tokyo Kasei Gakuin University
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Unno Tomonori
Central Research Institute Ito En Ltd.
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Kotani Kazuaki
Graduate School Of Medical Research Molecular Control Internal Medicine Osaka University:osaka Kenko
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Yabune Mitsuharu
Department Of Applied Biological Chemistry Osaka Prefecture University
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Yabune Mitsuharu
Department Of Clinical Trial And Research Soiken Inc.
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Kakuda T
Central Research Institute Ito En Ltd.
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Kakuda Takami
Central Research Institute Itoen Ltd.
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Kajimoto Osami
Health Management Center Osaka University Of Foreign Studies
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Yoshikawa Toshikazu
First Department Of Internal Medicine Kyoto Medical School
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Yoshikawa Toshikazu
First Department Internal Medicine Kyoto Prefectural University Of Medicine
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Nozawa Ayumu
Central Research Institute Ito En Ltd.
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Nozawa A
Research And Education Center For Genetic Information Nara Institute Of Science And Technology:(pres
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Kakuda Takami
Central Research Institute Ito En Ltd.
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Nakamura Tadashi
Graduate School Of Engineering Kanto Gakuin University
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Nakamura Tadashi
Graduate School Of Medical Research Molecular Control Internal Medicine Osaka University
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Nagata Kozo
Central Research Institute Ito En Ltd.
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UNNO Tomonori
Central Research Institute
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SAGESAKA Yuko
Central Research Institute
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NOZAWA Ayumu
Central Research Institute
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KAKUDA Takami
Central Research Institute
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SUZUKI Yuko
Central Research Institute
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