Inhibition by Theanine of Binding of [^3H] AMPA, [^3H] Kainate, and [^3H] MDL 105,519 to Glutamate Receptors(Biochemistry & Molecular Biology)
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概要
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In an investigation of the mechanisms of the neuroprotective effects of theanine (γ-glutamylethylamide) in brain ischemia, inhibition by theanine of the binding of [^3H] (RS) -α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA), [^3H] kainate, and [^3H] (E) -3- (2-phenyl-2-carboxyethenyl) -4, 6-dichloro-1-H-indole-2-carboxylic acid (MDL 105,519) to glutamate receptors was studied in terms of its possible inhibiting effects on the three receptor subtypes (AMPA, kainate, and NMDA glycine), with rat cortical neurons. Theanine bound the three receptors, but its IC_<50> of theanine was 80- to 30,000-fold less than that of L-glutamic acid.
- 社団法人日本農芸化学会の論文
- 2002-12-23
著者
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NIINO Hitoshi
Central Research Institute, ITO EN, LTD.
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KAKUDA Takami
Central Research Institute, Ito En, Ltd.
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Kakuda Takami
Department Of Legal Medicine Nihon University School Of Medicine
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Niino Hitoshi
Central Research Institute Ito En Ltd.
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Niino Hitoshi
Central Research Institute Itoen Ltd.
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Nozawa Ayumu
Central Research Institute, ITOEN, Ltd.
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Kakuda Takami
Central Research Institute Itoen Ltd.
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Nozawa Ayumu
Central Research Institute Ito En Ltd.
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Nozawa Ayumu
Central Research Institute Itoen Ltd.
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Sugimoto A
Itoen Ltd. Shizuoka Jpn
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Sugimoto Akio
Central Research Institute Itoen Ltd.
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Kakuda Takami
Central Research Institute Ito En Ltd.
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NOZAWA Ayumu
Central Research Institute
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KAKUDA Takami
Central Research Institute
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