Hydrolysis of Micellar Phosphatidylcholine Accelerates Cholesterol Absorption in Rats and Caco-2 Cells
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概要
- 論文の詳細を見る
Lymphatic recovery of cholesterol infused into the duodenum as bile salt micelles containing phosphatidylcholine (PC) was accelerated by the co-administration of phospholipase A2 in bile and pancreatic juice diverted rats. Previously we observed that cholesterol esterase, which has the ability to hydrolyze PC, caused the same effect under a similar experimental condition (Ikeda et al., Biochim. Biophys. Acta, 1571, 34–44 (2002)). Accelerated cholesterol absorption was also observed when a part of micellar PC was replaced by lysophosphatidylcholine (LysoPC) and oleic acid. Phospholipase A2 facilitated the incorporation of micellar cholesterol into Caco-2 cells in a dose-dependent manner. There was a highly negative correlation between the incorporation of cholesterol into Caco-2 cells and the content of micellar PC remaining in the culture medium. The release of cholesterol as a monomer from bile salt micelles was enhanced when a part of micellar PC was replaced with LysoPC and oleic acid. These results strongly suggest that the release of monomer cholesterol from bile salt micelles is accelerated by hydrolysis of PC in bile salt micelles and hence that cholesterol absorption is enhanced.
- 社団法人 日本農芸化学会の論文
著者
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IKEDA Ikuo
Laboratory of Food and Biomolecular Science, Graduate School of Agricultural Science, Tohoku Univers
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HAMADA Tadateru
Laboratory of Nutrition Chemistry, Faculty of Agriculture, Graduate School of Kyushu University
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IMAIZUMI Katsumi
Laboratory of Nutrition Chemistry, Faculty of Agriculture, Graduate School of Kyushu University
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Hamada Tadateru
Laboratory Of Nutrition Chemistry Faculty Of Agriculture Graduate School Of Kyushu University
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Hamada Tadateru
九州大学
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Hamada Tadateru
東北大学 農学研究科生体分子機能学
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Hamada Tadateru
九州大学 農学部栄養化学
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Hamada Tadateru
Laboratory Of Nutrition Chemistry Division Of Bioresource And Bioenvironmental Sciences Faculty Of A
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Ikeda Ikuo
九州大学
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KOBAYASHI Makoto
Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agricultur
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MATSUOKA Ryosuke
Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agricultur
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Ikeda Ikuo
Graduate School Of Agricultural Sci. Tohoku Univ.
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Ikeda Ichiro
Department Of Food Science And Technology Faculty Of Agriculture Kyushu University
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Kakuda Takami
Department Of Legal Medicine Nihon University School Of Medicine
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Kodama Yoko
Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agricultur
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Kakuda T
Central Research Institute Ito En Ltd.
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Kakuda Takami
Central Research Lnstitute Lto-en Ltd.
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Ikeda Ikuo
Laboratory Of Nutrition Chemistry Kyushu University School Of Agriculture
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Ikeda Ikuo
Division Of Applied Biological Chemistry Department Of Bioscience And Biotechnology Faculty Of Agric
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Ikeda Ikuo
Department Of Bioscience And Biotechnology Division Of Bioresource And Bioenvironmental Sciences Gra
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Imaizumi Katsumi
Laboratory Of Nutrition Chemistry Department Of Bioscience And Biotechnology Faculty Of Agriculture
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Ikeda Ikuo
東北大学 農学研究科生体分子機能学
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TAKASHIMA Kayoko
Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agricultur
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INOUE Takashi
Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agricultur
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Matsuoka Ryosuke
Laboratory Of Nutrition Chemistry Department Of Bioscience And Biotechnology Faculty Of Agriculture
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Ikeda Ikuo
Laboratory Of Food And Biomolecular Science Department Of Food Function And Health Graduate School O
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Kobayashi Makoto
Laboratory Of Food And Biomolecular Science Graduate School Of Agricultural Science Tohoku Universit
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Ikeda Ikuo
Laboratory Of Food And Biomolecular Science Department Of Food Function And Health Division Of Biosc
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Inoue Takashi
Laboratory For Developmental Neurobiology Brain Science Institute
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INOUE Takashi
Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University
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HAMADA Tadateru
Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University
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TAKASHIMA Kayoko
Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University
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KODAMA Yoko
Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University
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MATSUOKA Ryosuke
Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University
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IKEDA Ikuo
Laboratory of Food and Biomolecular Science, Department of Food Function and Health, Division of Bioscience and Biotechnology for Future Bioindustries, Graduate School of Agricultural Science, Tohoku University
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