Antigenic profiles of carcinoma cells of gastrointestinal tract, as detected by immunofluorescence technique.
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概要
- 論文の詳細を見る
Immunohistological studies were carried out on carcinoma cells of gastrointestinal system. The following results were obtained.1) Gastric mucosal glycoprotein, product of mucous cells in normal gastric mucosa and of Brunner's cells in the duodenum, was present in less or undifferentiated carcinoma cells of gastrointestinal tract but not in well-differentiated ones having the ordered glandular structures.2) Intestinal mucosa-specific mucosal glycoprotein, product of goblet cells in normal intestinal mucosa, was present only in gastrointestinal carcinomas of less orderly arranged glandular structures, similarly to gastric mucosal glycoprotein. It was also present in the intestinalized gastric glands.3) Placental alkaline phosphatase isoenzyme was present in carcinoma cells of both differentiated and undifferentiated type in gastrointestinal tract, but in neither intestinalized cells nor connective tissue components.4) Serum glycoprotein was found to attach firmly to carcinoma cells as "Symbodies", resulting in the immunological unresponsiveness.5) Crossreacting antigen between gastric tumor and some normal proliferating cells (some lymphocytes of the spleen and bone marrow, and alveolar epithelial cells of the lung) was demonstrated on immunofluorescent tissue preparations.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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Kakuda Takami
Department Of Legal Medicine Nihon University School Of Medicine
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Abe Takaaki
Institute Of Earth And Space Science Graduate School Of Science Osaka University
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Kimoto Eiji
Department Of Chemistry Faculty Of Science Fukuoka University
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Takeuchi Mutsuya
Institute Of Clinical Pathology Kurume University School Of Medicine
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Kawasaki Hiroshi
Institute Of Medical Science University Of Tokyo
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TAKADA Akiko
Department of Pediatrics, Jichi Medical University School of Medicine
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AKAGI YOSHIHIRO
Institute of Clinical Pathology, Kurume University School of Medicine
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ABE TAKAAKI
Institute of Clinical Pathology, Kurume University School of Medicine
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TAKADA AKIKO
Department of Chemistry, Faculty of Science, Fukuoka University
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KAWASAKI HIROSHI
Institute of Clinical Pathology, Kurume University School of Medicine
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