BIOCHEMICAL RESEARCH ON THE INFLUENCE OF PLACENTA PLASMA UPON THE LIVER INJURYCAUSED BY CARBON TETRACHLORIDE

概要

論文の詳細を見る
One of the present authors (1) reported that Placenta Plasma and Nea Placenta Plasma (2, 3) prevent or remove an accumulation of excess fat in the liver of rat followed by administration of carbon tetrachloride. In this work, further detailed stgdies on the lipotropic action of Placenta Plasma were performed by the biochemical methods. Ten years ago, the mechanism of lipotropic action was indicated by Perlman, Chaikoff, Welch, Landau and Du Vigneaud (4, 5). They settled a hypothesis that the lipotropic agent is incorporated into the phospholipid molecule which facilitates in some manner to transport and to metabolize fatty acids, and that dietary choline is rapidly incorporated into liver lecithin and methionine exerts its lipotropic effect by denoting its labile methyl group for biosynthesis of choline. Perlman (6), Artom (7) and Cornatzer (8) found that choline or methionine accelerates the rate of turnover of the phosphorous in the phosphatides while cholin deprivation retards the rate of incorporation of new choline into the phosphatides which is synthesized mainly in the liver. Lichtman (4) said that both lecithin formation and fatty acid metabolism probably depend upon the concentration of free choline in the liver cells, but there is no conclusive evidence for the hypothesis that the prevention of the fatty infiltration is the result of an increased turnover of liver phospholipids. According to the recent investigations it seems more likely that the lipotropic effect of choline and methionine may result, at least to a large extent, from the enhancement of fatty acid oxidation in the liver itself rather than by promoting the fat mobilization in the form of plasma phospholipids. Artom (9) found that the oxidation of isotopic long chain fatty acids is depressed in the liver preparations of choline-deficient animals, and that choline, administered in vivo, restores the ability of tissue to oxidize the labile fatty acids at a high rate. Recently, the significance of coenzyme A on the fat metabolism is recognized. And it is considered as an area to be studied very actively in the next few years that the formation of acetyl coenzyme A may be sensitive to the deprivation of sulfur amino acids or panthothenic acid in animal (10). The present authors studied on the relation between the fatty accumulation and the metabolic disturbance of liver administered by carbon tetrachloride and intended to clarify the mode of action of Placenta Plasma on the liver injury.
久留米大学医学部 The Kurume Medical Journal 編集部の論文

BIOCHEMICAL RESEARCH ON THE INFLUENCE OF PLACENTA PLASMA UPON THE LIVER INJURYCAUSED BY CARBON TETRACHLORIDE

スポンサーリンク

概要

著者

関連論文

スポンサーリンク