ACID MUCOPOLYSACCHARIDES IN ATHEROSCLEROSIS
スポンサーリンク
概要
- 論文の詳細を見る
Interest in the ground substance of vascular structures has been evoked by the advancement of histo-pathological studies on the atherosclerosis, emphasizing the possible role of mucopolysaccharide accumulation in the production of focal atheroma. Such histochemical observations on arterial mucopolysaccharide have stimulated the extension of the biochemical knowledge on their nature and metabolim. The questions were reviewed from the recent informations including some of our studies concerned. Our experiments at the first step were carried out on the gross aortic materials to overlook the changing pattern of total and fractionated AMPS with aging and atherosclerosis. At the next step, further microtechnique was introduced to permitting the analysis on the aortic material comprising as small as one intimal lesion, which was composed of the microscale extraction procedure including the selective precipitation with cation detergent and the densitometric determination of AMPS fractions after electrophoretic separation on cellulose acetate strip. The experiments have evidenced the facts that aging of aortic tissue appears to be characterized by a decline of total AMPS contents in aceton-dry tissue and a decrease in hyaluronic acid and chondroitinsulfate A or C content and an increase in chondroitinsulfate B, similarly to the aging skin or cartilage, and that the edematous lesions, perhaps an early phase of fibrous plaque, comprise both high AMPS value and hyaluronic acid content. The possible biological functions of AMPS on atherogenesis were also reviewed from the recent publications. AMPS was recognized to possess the properties of preventing thrombus formation and lipid deposition in the arterial wall through its antithrombin and lipid clearing activity and, on the other hand, those of inducing the fibrin and lipid deposit through physicochemical complex formation with fibrinogen and lipoprotein. The destruction or abnormal aggregation of AMPS in the ground substance might cause an increased permeability of the arterial wall to the circulating lipoprotein and also the destruction of connective tissue fibers, substantially inducing the atherosclerosis.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
-
Kimoto Eiji
Institute Of Clinical Pathology Kurume University School Of Medicine
-
Takeuchi Mutsuya
Institute Of Clinical Pathology Kurume University School Of Medicine
-
Tanaka Yukio
Institute Of Informaition And Computer Science:japan Technical Software Ltd. Shin-ohdohri Bldg.
-
TANAKA YUKIO
Institute of Clinical Pathology, Kurume University School of Medicine
関連論文
- STUDY ON THE HYPOPROTEINEMIA AFTER OPEN-HEART OPERATION : PROCEEDINGS OF THE 37TH ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
- THE DISTRIBUTION OF TAMM-HORSFALL GLYCOPROTEIN IN URINARY SYSTEM OTHER THAN KIDNEY AND IN PROSTATE GLAND
- IMMUNOFLUORESCENT STUDY ON THE ORIGIN OF TAMM-HORSFALL GLYCOPROTEIN
- ANTIGENIC PROFILES OF CARCINOMA CELLS OF HUMAN GASTROINTESTINAL TRACT, AS DETECTED BY IMMUNOFLUORESCENCE TECHNIQUES
- IMMUNOFLUORESCENT STAINING OF MUCOSAL GLYCOPROTEIN OF HUMAN INTESTINAL MUCOSA
- Distribution of Gastric Mucosa-Specific Glycoprotein in Gastric Cancer Tissues as Detected by Immunofluorescence Technique.
- A Structural Model for B_2O_3 Glass-An Analysis of Neutron and X-Ray Data by a Liquid Model-
- ANTIGENIC PROFILES OF PROTEINPOLYSACCHARIDE COMPLEX FROM HUMAN COSTAL CARTILAGE:II. DENSITY GRADIENT SEDIMENTATION OF THE ANTIGENIC COMPONENTS
- ANTIGENIC PROFILES OF PROTEINPOLYSACC ARIDE COMPLEX FROM HUMAN COSTAL CARTILAGE:I. ANTIGENICITY OF SIALOPROTEIN MOIETY
- Further studies on the distribution of glycosaminoglycans in the human heart.
- Immunological studies on the influences of isolation procedures upon contents of urinary glycoprotein and glycosaminoglycans.
- DISTRIBUTION OF THE GLYCOSAMINOGLYCANS IN THE ABDOMINAL WALLS OF THE RATS
- Immunological studies on Tamm-Horsfall glycoprotein in the urine of patients with renal diseases.
- Isolation and characterization of glycosaminoglycans from the bovine fourth stomach.
- Fractionation of urinary glycopeptide by DEAE Sephadex A-50 column chromatography.
- Isolation and partial characterization of a glycopeptide from cerumen.
- Antigenic profiles of carcinoma cells of gastrointestinal tract, as detected by immunofluorescence technique.
- Excretion patterns of glycosaminoglycans in the urine of normal children and adults.
- A RAPID METHOD FOR DETERMINATION OF URINARY KERATAN SULFATE IN THE HEREDITARY MUCOPOLY-SACCHARIDOSIS IV (MORQUIO SYNDROME)
- ACID MUCOPOLYSACCHARIDES IN ATHEROSCLEROSIS
- GLYCOPEPTIDE AND GLYCOSAMINOGLYCAN IN THE URINE OF THE HEREDITARY MUCOPOLYSACCHARIDOSIS VI (MAROTEAUX-LAMY SYNDROME)
- IMMUNOFLUORESCENT STAINING OF THE GASTRIC MUCOSAL GLYCOPROTEIN IN FETAL GUT
- SOME CHARACTERISTICAL CHANGES IN MUCIN OF HUMAN AORTA WITH AGING AND DEVELOPING ATHEROSCLEROSIS