Antitumor-active Heteroglycans from Niohshimeji Mushroom, Tricholoma giganteum
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概要
- 論文の詳細を見る
Water-soluble polysaccharide FI and water-insoluble polysaccharides FII, FIII-1, and FIII-2 were obtained from fruiting bodies of Tricholoma giganteum. Polysaccharides were further fractionated by ion-exchange chromatography, gel filtration, and affinity chromatography. The 24 polysaccharide fractions obtained were examined for their antitumor effect on Sarcoma 180 implanted in mice. The following antitumor-active polysaccharides were identified : FIo-a, a mixture of α-D-glucan and xyloglucomannan with an average molecular weight of 1. 6× 10^6 ; FA-1, a β-D-glucan containing 1% protein and with a molecular weight of 4.O×10^4 ; FII-1, a (1→3)-β-D-glucan containing 7.8% protein, with a molecular weight of 5.2×10^4 ; FIII-1-b, a protein-polysaccharide complex (ratio, 37.5 : 62.5, w/w), with a molecular weight of 6.8×10^4 and with xylose, galactose, mannose, and glucose in the polysaccharide moiety (proportions of 8.9 : 14.9 : 29.3 : 46.9 by weight), and FIII-2-a, b, and c, three (1→6)-β-D-glucosyl-branched (1→3)-β-D-glucans with a molecular weight from 2.6×10^5 to 4.1×1O^5 and containing small amounts of xylose and galactose and 3.5-8.30% protein.
- 社団法人日本農芸化学会の論文
- 1995-04-23
著者
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ITO Hitoshi
Department of Radiology, Okitama Public General Hospital
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Ma Yan
Faculty Of Basic Medical Science Norman Bethune University Of Medical Science
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Ma Y
Univ. Southern California Ca Usa
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Mayuzumi Yoshikazu
Myogi Mushroom Development
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Kakuda Takami
Department Of Legal Medicine Nihon University School Of Medicine
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Ito H
National Agricultural Res. Organization Mie Jpn
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Kakuda Takami
Central Research Lnstitute Lto-en Ltd.
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KINOSHITA TETSUYA
Department of Orthopaedic Surgery, Shinshu University School of Medicine
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MIZUNO Takashi
Department of Bioresource Science, Faculty of Agriculture, Tottori University
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Mayuzumi Yoshikazu
Myogi Mushroom Development Farm
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Ito Hiroyuki
Precision And Intelligence Laboratory Tokyo Institute Of Technology
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Ma Y
Departments Of Materials Science And Mechanical Engineering University Of Southern California
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Zhuang Cun
The United Graduate School Of Agricultural Sciences (shizuoka University) Gifu University
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Itoh H
Osaka Univ. Pharmaceutical Sci. Osaka Jpn
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Ito Hitoshi
The Japan Atomic Energy Research Institute Takasaki Radiation Establishment
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Zhuang Cun
United Graduate School of Agricultural Sciences,Gifu University(Shizuoka University)
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Ito H
Precision And Intelligence Laboratory Tokyo Institute Of Technology
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Kinoshita Tetsuya
Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University
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Mizuno Takashi
Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University
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Mizuno Takashi
Department Of Agricultural Chemistry Shizuoka University
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Ito Hitoshi
Department Of Pharmacology Mie University School Of Medicine
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Mizuno Takashi
Department Of Agricultural Chemistry Faculty Of Agriculture Shizuoka University
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ITO Hitoshi
Department of Chemistry, College of Science and Engineering, Aoyama Gakuin University
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