Fractionation and Characterization of Antitumor Polysaccharides from Maitake, Grifola frondosa(Biological Chemistry)

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概要

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• Three groups of polysaccharides from the edible mushroom "Maitake," the cultured fruiting body of Grifola frondosa, were extracted with hot water, 3% NH_4-oxalate (100℃), and 5% sodium hydroxide solution (30℃) in this order. The three fractions, FI, FII and FIII, were divided into several sub-fractions using various chromatographic techniques. The fractions with host-mediated antitumor activity were as follows: Water-soluble β-(1→3)-D-glucan: FI_0-a-β_1; [α]_D +9°(water), <MW>^^^- 1,000,000, N 0%, degree of branching=3, average chain-length=5, ID_<50> (the dose level, mg/kg in mice, inhibiting tumor growth in 50% of animal controls)= 5.8. Water-soluble acidic β-D-glucan: FA-la-β_1, [α]_D+5°(water), <MW>^^^- 500,000, component sugars; Glc 82.4% and GlcUA 8.8%, ID_<50>=12.9. Water-insoluble acidic xyloglucan: FII-3, [α]_D+56°(NaOH), <MW>^^^- 50,000, component sugars; Glc:Xyl=100:82, GlcUA 16.5%, ID_<50>=23.8. Acidic hetero-glycan: FIII-1a, [α]_D+6°(NaOH), <MW>^^^- 100,000〜250,000, protein content 3.8%, component sugars; Glc:Xyl:Man:Fuc=100:58:34:14, GlcUA 20.4%, ID_<50>=16.1. Acidic glycoproteins: FIII-2a, FIII-2b and FIII-2c: [α]_D+58°, +43°, -11°(NaOH); <MW>^^^- 1,000,000, 70,000〜100,000, 20,000〜50,000; ID_<50>=38.5, 13.9, 9.3 respectively; component sugars; major=Glc, minor=Fuc, Xyl, Man, and Gal. None of the polysaccharides intraperitoneally active against mouse-implanted Sarcoma 180 had any activity orally.

• 社団法人日本農芸化学会の論文
• 1986-07-23

著者

• MIZUNO Takashi

  Department of Bioresource Science, Faculty of Agriculture, Tottori University

• HAGIWARA Nobuyuki

  Central Research Laboratories, Taiyo Kagaku Co., Ltd.

• Ohsawa Keiko

  Department Of Agricultural Chemistry Faculty Of Agriculture Shizuoka University

• Hagiwara N

  Central Research Laboratories Taiyo Kagaku Co. Ltd.

• HAGIWARA Naomi

  Department of Agricultural Chemistry, Faculty of Agriculture, Shizuoka University

• KUBOYAMA Reiko

  Department of Agricultural Chemistry, Faculty of Agriculture, Shizuoka University

• Kuboyama Reiko

  Department Of Agricultural Chemistry Faculty Of Agriculture Shizuoka University

• Mizuno Takashi

  Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University

• Mizuno Takashi

  Department Of Agricultural Chemistry Shizuoka University

• Mizuno Takashi

  Department Of Agricultural Chemistry Faculty Of Agriculture Shizuoka University

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