EFFECT OF OXYGEN AND SUPEROXIDE ANION ON MUTATION RATE IN AMES TEST
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概要
- 論文の詳細を見る
Effects of oxygen and superoxide anion to mutation rate were examined using the method of Ames. As test samples, 3-methylcholanthrene or 3, 4-benzpyrene dissolved in squalene was used. In order to increase the concentration of dissolved oxygen in the medium during preincubation, oxygen was bubbled into the medium. Various combinations of xanthine oxidase, superoxide dismutase and hypoxanthine were used with an intent of changing the concentration of superoxide anion in the medium during the preincubation. An increase in the concentration of dissolved oxygen and superoxide anion resulted in a lower mutation rate, clearly showing the relationships of mutation rate with oxygen and with superoxide anion.
- 日本トキシコロジー学会の論文
- 1985-05-25
著者
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YOKOTA Takashi
Department, of Information Science, Graduate School of Engineering, Utsunomiya University
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Yokota Takashi
Department Of Analytical Chemistry Faculty Of Pharmaceutical Sciences Hoshi University
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OHSAWA Keiko
Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Hoshi University
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IMAEDA Kazuo
Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Hoshi University
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Imaeda Kazuo
Department Of Analytical Chemistry Faculty Of Pharmaceutical Sciences Hoshi University
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Imaeda K
Department Of Analytical Chemistry Faculty Of Pharmaceutical Sciences Hoshi University
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Ohsawa K
Shizuoka Univ.
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Ohsawa Keiko
Department Of Agricultural Chemistry Faculty Of Agriculture Shizuoka University
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