野生型およびTsix遺伝子変異ES細胞の分化誘導時におけるXist遺伝子座ヒストン修飾の変化
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概要
- 論文の詳細を見る
The non-coding RNA Xist is indispensable for X chromosome inactivation. Transcriptional control of Xist gene depends on its antisense partner gene Tsix which prevents Xist up-regulation in cis. Previous studies proposed Tsix acts by regulating chromatin structure. Although histone modifications in the Xist locus during differentiation have been described in female embryonic stem (ES) cells, they remain unclear in males. Here we addressed histone modifications in the Xist locus in wild-type and Tsix-mutant male ES cells during differentiation. Their active and repressive modifications were attenuated upon differentiation, while the histone modification profile in males resembled that of females in an undifferentiated condition. These results provide implications in understanding the regulation of Xist gene, as well as other developmentally regulated genes, through chromatin structure.
- 社団法人 日本実験動物学会の論文
著者
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YOKOTA Takashi
Department, of Information Science, Graduate School of Engineering, Utsunomiya University
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柴田 進和
金沢大学医学系研究科再生分子医学教室
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横田 崇
金沢大学医学系研究科再生分子医学教室
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柴田 進和
Department of Stem Cell Biology, Graduate School of Medicine, Kanazawa University
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横田 崇
Department of Stem Cell Biology, Graduate School of Medicine, Kanazawa University
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Yokota Takashi
Department Of Analytical Chemistry Faculty Of Pharmaceutical Sciences Hoshi University
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SHIBATA Shinwa
Department of Stem Cell Biology, Graduate School of Medicine, Kanazawa University
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