Antitumor Effects of β-Subunit from Egg White Ovomucin on Xenografted Sarcoma-180 Cells in Mice
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概要
- 論文の詳細を見る
The intraperioneal administration of β-subunit prepared from egg white ovomucin was found to suppress the growth of subcutaneously xenografted sarcoma-180 cells in mice and cure the tumor. In the present system, β-subunit (5 mg/kg of body weight) was injected to mice daily for 19 days after the 10th day when tumors had grown to 7 mm in diameter. The light and electron microscopic appearances of tumor portions on day 28 showed that β-subunit-treated tumor cells were in the states of degenerated and necrotic cells, and massive accumulations of neutrophils, macrophages and lymphocytes were found at the margin of the degenerated and necrotic tumor tissue area. These findings suggested that β-subunit brought about the regression of tumor, probably by activating the immune system.
- 社団法人 日本食品科学工学会の論文
- 1999-08-01
著者
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YOKOTA Takashi
Department, of Information Science, Graduate School of Engineering, Utsunomiya University
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Yokota Takashi
Department Of Pathology Institute Of Gerontology Nippon Medical School
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WATANABE Kenji
Faculty of Pharmaceutical Sciences, Fukuoka University
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OHISHI Hifumi
Fundamental Research Laboratory, Kyodo Milk Industry Co., Ltd.
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Ohishi Hifumi
Fundamental Research Laboratory Kyodo Milk Industry Co. Ltd.
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Watanabe Kensuke
Ichimaru Pharcos Co. Ltd.
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Yokota Takashi
Department Of Analytical Chemistry Faculty Of Pharmaceutical Sciences Hoshi University
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Watanabe Kenji
Faculty Of Fisheries Kagoshima University
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WATANABE Kenji
Faculty of Agriculture, Gifu University
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