Lower aerobic capacity was associated with abnormal intramuscular energetics in patients with metabolic syndrome
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概要
- 論文の詳細を見る
Lower aerobic capacity is a strong and independent predictor of cardiovascular morbidity and mortality in patients with metabolic syndrome (MetS). However, the mechanisms are not fully elucidated. We tested the hypothesis that skeletal muscle dysfunction could contribute to the lower aerobic capacity in MetS patients. The incremental exercise tests with cycle ergometer were performed in 12 male patients with MetS with no habitual exercise and 11 age-, sex-, and activity-matched control subjects to assess the aerobic capacity. We performed 31phosphorus-magnetic resonance spectroscopy (31P-MRS) to assess the high-energy phosphate metabolism in skeletal muscle during aerobic exercise. Proton(1H)-MRS was also performed to measure intramyocellular lipid (IMCL) content. Peak oxygen uptake (peak VO2; 34.1 ± 6.2 vs. 41.4 ± 8.4 mL/kg/min, P < 0.05) and anaerobic threshold (AT; 18.0 ± 2.4 vs. 23.1 ± 3.7 mL/kg/min, P < 0.01) adjusted by lean body mass were lower in MetS patients than control subjects. Phosphocreatine (PCr) loss during exercise was 1.5-fold greater in MetS, suggesting reduced intramuscular oxidative capacity. PCr loss was inversely correlated with peak VO2 (r = -0.64) and AT (r = -0.60), respectively. IMCL content was 3-fold higher in MetS and was inversely correlated with peak VO2 (r = -0.47) and AT (r = -0.52), respectively. Moreover, there was a positive correlation between IMCL content and PCr loss (r = 0.64). These results suggested that lean-body aerobic capacity in MetS patients was lower compared with activity-matched healthy subjects, which might be due to the reduced intramuscular fatty acid oxidative metabolism.
- Nature Publishing Groupの論文
- 2011-09-01
著者
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KINUGAWA Shintaro
Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine
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Kinugawa Shintaro
Department Of Cardiovascular Medicine Hokkaido University Graduate School Of Medicine
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Kinugawa Shintaro
Department Of Cardiovascular Medicine Hokkaido University
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Togashi Hiroko
北海道大学
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Okita Koichi
Graduate School Of Program In Lifelong Learning Studies Hokusho University
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Takada Singo
Graduate School Of Program In Lifelong Learning Studies Hokusho University
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Yokota Takashi
Department Of Cardiovascular Medicine Hokkaido University Graduate School Of Medicine
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Suga Tadashi
Department Of Cardiovascular Medicine Hokkaido University Graduate School Of Medicine
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Hirabayashi Kagami
Department Of Cardiovascular Medicine Hokkaido University
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Tsutsui Hiroyuki
Department Of Cardiovascular Medicine
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Horiuchi Masahiro
Department Of Cardiovascular Medicine Hokkaido University Graduate School Of Medicine
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Tsutsui Hiroyuki
Department Of Cardiovascular Medicine Kyushu University Graduate School Of Medical Sciences
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Tsutsui Hiroyuki
Department Of Cardiovasucular Medicine Graduate School Of Medical Sciences Kyushu University
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Yokota Takashi
Department Of Analytical Chemistry Faculty Of Pharmaceutical Sciences Hoshi University
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Tsutsui Hiroyuki
Department Of Cardiovascular Medicine Hokkaido University Hospital
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Hattori Masaaki
Department Of Community Development Hokkaido Tokai University
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Nakagawa Yoshinao
Department of Health and Sport Sciences, Otaru University
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Shirato Hiroki
Department Of Diagnostic And Interventional Radiology Hokkaido University Hospital
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Oyama Manabe
Department Of Diagnostic And Interventional Radiology Hokkaido University Hospital
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Nakagawa Yoshinao
Department Of Health Science Otaru University
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Tsutsui Hiroyuki
Departments Of Cardiovascular Medicine Graduate School Of Medical Sciences Kyushu University:japanese Coronary Intervention Study (jcis) Group
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Oyama-Manabe Noriko
Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital
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TSUTSUI Hiroyuki
Department of Cardiology, Iizuka Hospital
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Okita Koichi
Graduate School of Lifelong Learning Studies, Hokusho University
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Oyama-Manabe Noriko
Department of Diagnostic and Interventional Radiology, Hokkaido University Graduate School of Medicine
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