Lipoprotein Metabolism, Insulin Resistance, and Adipocytokine Levels in Japanese Female Adolescents With a Normal Body Mass Index and High Body Fat Mass(Vascular Medicine)

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Background: The prevalence of obesity is gradually increasing in Japan, but in women aged in their 20s to 50s it has been disproportionately decreasing. However, the exact body composition of this subset of the population has not been elucidated. Methods and Results: Body composition was determined using whole-body dual energy X-ray absorptiometry and metabolic parameters in 157 Japanese female university students (21.1±1.9 years); 31 women had a normal body mass index (BMI), but an increased body fat mass (BFM). Only the 31 had significantly higher low-density lipoprotein-cholesterol levels (90.5 vs 99.0mg/dl, P<0.01) and leptin concentration (7.0 vs 4.6ng/ml, P<0.05) and lower high-density lipoprotein-cholesterol (80.4±15.1 vs 73.5±14.5mg/dl, P<0.01) than females with normal BMI and normal BFM. Conclusions: A considerable number of young Japanese women with a normal BMI have excess BFM and relatively higher lipid and leptin levels. These findings may provide an important basis for future epidemiological surveys and studies.
社団法人日本循環器学会の論文
2009-02-20