Discharge use of angiotensin receptor blockers provides comparable effects with angiotensin-converting enzyme inhibitors on outcomes in patients hospitalized for heart failure

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• Large-scale, placebo-controlled, randomized clinical trials have demonstrated that angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs) reduce mortality and hospitalization in patients with heart failure (HF) caused by left ventricular systolic dysfunction (LVSD). However, it is unknown whether ACE inhibitors and ARBs have similar effects on the long-term outcomes in HF patients encountered in routine clinical practice. The Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) enrolled HF patients hospitalized with worsening symptoms and they were followed during an average of 2.2 years. The outcome data were compared in patients with LVSD by echocardiography (ejection fraction <40%) according to the predischarge use of ACE inhibitors (n=356) or ARBs (n=372). The clinical characteristics were similar between patients with ACE inhibitor and ARB use except for higher prevalence of hypertensive etiology and diabetes mellitus. There was no significant difference between ACE inhibitor and ARB use in all cause death (adjusted hazard ratio [HR] 0.958, 95% CI 0.601-1.527, P=0.858) and rehospitalization (adjusted HR 0.964, 95% CI 0.683-1.362, P=0.836). The effects of ACE inhibitor and ARB use on the outcomes were generally consistent across all clinically relevant subgroups examined, including age, sex, etiology, EF, hypertension, diabetes mellitus, and β-blocker use. Discharge use of ARBs provided comparable effects with ACE inhibitors on outcomes in patients hospitalized for HF. These findings provide further support for guideline recommendations that ARBs can be used in patients with HF and LVSD as an alternative of ACE inhibitors.

• 2010-03-01

著者

• Takeshita Akira

  Saiseikai Futsukaichi Hospital

• Tsutsui Hiroyuki

  Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Hokkaido University

• Yoshida H

  Department Of Cardiovascular Medicine Hokkaido University Graduate School Of Medicine

• Yokoshiki Hisashi

  Department Of Cardiovascular Medicine Hokkaido University Graduate School Of Medicine

• TSUCHIHASHI MAKAYA

  Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine

• FURUMOTO Tomoo

  Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine

• KINUGAWA Shintaro

  Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine

• HAMAGUCHI Sanae

  Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine

• GOTO Kazutomo

  Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine

• GOTO Daisuke

  Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine

• YAMADA Satoshi

  Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine

• TAKESHITA Akira

  Futsukaichi Saiseikai Hospital

• Kinugawa Shintaro

  Department Of Cardiovascular Medicine Hokkaido University Graduate School Of Medicine

• Kinugawa Shintaro

  Department Of Cardiovascular Medicine Hokkaido University

• Goto Daisuke

  Department Of Cardiovascular Medicine Hokkaido University Graduate School Of Medicine

• Gotoh Kazutomo

  Department Of Cardiovascular Medicine Hokkaido University Graduate School Of Medicine

• Takeshita A

  Futsukaichi Saiseikai Hospital

• Hamaguchi Sanae

  Department Of Cardiovascular Medicine Hokkaido University Graduate School Of Medicine

• Takeshita Akira

  国立国際医療センター研究所 医療情報解析研究部

• Tsuchihashi Miyuki

  Department Of Cardiovascular Medicine Hokkaido University Graduate School Of Medicine

• Togashi Hiroko

  筑波大学 臨床医学系循環器内科

• Togashi Hiroko

  北海道大学 医学研究科 薬理

• Togashi Hiroko

  北海道大学

• Tsuchihashi-Makaya Miyuki

  Department of Gene Diagnostics and Therapeutics, Research Institute, International Medical Center of

• Tsutsui Hiroyuki

  Department Of Cardiovascular Medicine

• Goto Kazutomo

  Department Of Cardiovascular Medicine Hokkaido University Graduate School Of Medicine

• Yamada Satoshi

  Department Of Cardiovascular Medicine Hokkaido University Graduate School Of Medicine

• Furumoto Tomoo

  Department Of Cardiovascular Medicine Hokkaido University Graduate School Of Medicine

• Togashi Hiroko

  Department Of Pharmacology Hokkaido University Graduate School Of Medicine

• Makaya Miyuki

  Kyushu University Graduate School Of Medical Sciences

• Togashi Hiroko

  Safety Research Institute For Chemical Compounds

• Tsutsui Hiroyuki

  Department Of Cardiovasucular Medicine Graduate School Of Medical Sciences Kyushu University

• Togashi Hiroko

  Department Of Cardiovascular Medicine Hokkaido University Graduate School Of Medicine

• Makaya Miyuki

  Department Of Cardiovasucular Medicine Graduate School Of Medical Sciences Kyushu University

• Yokoi Hisataka

  Department Of Cardiovascular Medicine Hokkaido University Graduate School Of Medicine

• Togashi Hiroko

  1st Dept. Of Pharmacol. Hokkaido Univ. Sch. Of Med.

• Tsutsui Hiroyuki

  Department Of Cardiovascular Medicine Hokkaido University Hospital

• Takeshita Akira

  Department Of Cardiovascular Medicine Hokkaido University Graduate School Of Medicine

• Tsuchihashi Makaya

  Department Of Cardiovascular Medicine Hokkaido University Graduate School Of Medicine

• Makaya Miyuki

  International Medical Center Of Japan

• Tanaka Atsushi

  Department Of Cardiovascular Medicine Kyushu University

• Tsuchihashi Makaya

  Department Of Clinical Research And Informatics Research Institute International Medical Center Of J

• Tsuchihashi Makaya

  Department Of Clinical Research And Informatics Research Institute International Medical Center Of J

• Togashi Hiroko

  Department Of Neuropharmacology Hokkaido University Graduate School Of Medicine

• Tsuchihashi Makaya

  Department Of Clinical Research And Informatics Research Institute International Medical Center Of J

• Tsuchihashi-Makaya Miyuki

  Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine

• TSUTSUI Hiroyuki

  Department of Cardiology, Iizuka Hospital

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