Early postnatal stress affects 5-HT1A receptor function in the medial prefrontal cortex in adult rats
スポンサーリンク
概要
- 論文の詳細を見る
Traumatic events in early life are associated with an increased risk of psychiatric diseases in adulthood. 5-hydroxytryptamine (5-HT)1A receptors are known to play a pivotal role in the 5-HTergic mechanisms associated with the etiology of stress-related disorders. The goal of the present study was to investigate whether early postnatal stress influences 5-HT1A receptor function in the medial prefrontal cortex in adult rats. Rats were subjected to aversive foot shock (FS) during the third week of the postnatal period (3wFS group). During the postadolescent period (10-14 weeks postnatal), immunohistochemical experiments were carried out to investigate c-Fos expression following the administration of R-(+)-8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), a 5-HT1A receptor agonist. In the 3wFS group, the 8-OH-DPAT-induced c-Fos expression in the medial prefrontal cortex was significantly attenuated compared to that in the non-FS control group. A dual immunofluorescence study revealed that a small proportion of c-Fos positive cells co-express parvalbumin, and a relatively large proportion of c-Fos positive cells co-express glutaminase, suggesting that most c-Fos positive cells are glutamatergic neurons. We found that local perfusion of 8-OH-DPAT via a dialysis probe decreased extracellular 5-HT levels in the medial prefrontal cortex of the non-FS group, but not in the 3wFS group. However, the levels of 8-OH-DPAT-induced 5-HT syndrome were not significantly different between the non-FS and 3wFS groups. Therefore, aversive stress in the third week of the postnatal period attenuates 5-HT1A receptor function in the medial prefrontal cortex in adulthood and produces feedback inhibition of the raphe nuclei via postsynaptic 5-HT1A receptors.
- Elsevier B.V.の論文
- 2009-08-01
著者
-
Matsumoto M
Department Of Microbiology And Immunology Hokkaido University Graduate School Of Medicine
-
Minami Masaru
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
-
Togashi Hiroko
北海道大学 医学研究科 薬理
-
Togashi Hiroko
北海道大学
-
Togashi Hiroko
Department Of Pharmacology Hokkaido University School Of Medicine
-
松本 美佐子
Department Of Microbiology And Immunology Hokkaido University Graduate School Of Medicine
-
Yoshioka Mitsuhiro
Facul.of Pharm.sci. Higashi-nippon-gakuen Univ. 1st Dept.of Pharmacol
-
Yoshioka Mitsuhiro
Hokkaido University Graduate School of Medicine
-
Togashi Hiroko
Department Of Pharmacology Hokkaido University Graduate School Of Medicine
-
Togashi Hiroko
Safety Research Institute For Chemical Compounds
-
Tsutsui Hiroyuki
Department Of Cardiovasucular Medicine Graduate School Of Medical Sciences Kyushu University
-
Minami Masaru
Department Of Cardiovascular Medicine Hokkaldo University School Of Medicine
-
Minami Masaru
Dep. Of Pharmacology Fac. Of Pharmaceutical Sciences Health Sciences Univ. Of Hokkaido
-
Togashi Hiroko
1st Dept. Of Pharmacol. Hokkaido Univ. Sch. Of Med.
-
Makita Masaaki
Dept. Of Cardiovascular Med Hokkaido Univ.
-
Minami Masaru
Dept. Of Pharm. School Of Med. Hokkaido Univ.
-
Yamaguchi Taku
Department Of Neuropharmacology Hokkaido University Graduate School Of Medicine
-
Togashi Hiroko
Department Of Neuropharmacology Hokkaido University Graduate School Of Medicine
-
Izumi Takeshi
Department Of Neuropharmacology Hokkaido University Graduate School Of Medicine
-
Yoshida Takayuki
Department Of Neuropharmacology Hokkaido University Graduate School Of Medicine
関連論文
- Phylogenetic and expression analysis of lamprey toll-like receptors
- The Peptide Sequence of Diacyl Lipopeptides Determines Dendritic Cell TLR2-Mediated NK Activation
- Innate Immune Therapy with a Bacillus Calmette-Guerin Cell Wall Skeleton After Radical Surgery for Non-Small Cell Lung Cancer : A Case-Control Study
- Tumor immunotherapy using bone marrow-derived dendritic cells overexpressing Toll-like receptor adaptors
- IL-6 and IFN-α from dsRNA-stimulated dendritic cells control expansion of regulatory T cells
- Dendritic cell-derived TNF-α is responsible for development of IL-10-producing CD4+ T cells
- An embryo-specific expressing TGF-β family protein, growth-differentiation factor 3 (GDF3), augments progression of B16 melanoma
- TLRを介したタイプ1インターフェロン産生にかかわるアダプター分子TICAM-1 (免疫2004) -- (自然免疫)
- 臨床応用 Toll-like receptorと免疫療法 (特集 シグナル伝達の基礎と臨床応用)
- ヒト精巣より得られた新種のCD46(Membrance cofacter protein)splicing product受精レセプターCD46との類似性
- TLRシグナルによるクロスプレゼンテーション制御機構 (特集 樹状細胞の機能制御)
- Hepatitis C Virus Core Protein Abrogates the DDX3 Function That Enhances IPS-1-Mediated IFN-Beta Induction
- Identification of a polyI:C-inducible membrane protein that participates in dendritic cell-mediated natural killer cell activation
- The ubiquitin ligase Riplet is essential for RIG-I-dependent innate immune responses to RNA virus infection.
- 30 Toll-like receptor 3の細胞外ドメインと特異的に結合するRNA aptamerの獲得(一般講演,第31回学術講演会講演要旨集)
- Diazepam-Induced Increases of Synaptic Efficacy in the Hippocampal – Medial Prefrontal Cortex Pathway Are Associated With Its Anxiolytic-like Effect in Rats
- Strain-to-strain difference of V protein of measles virus affects MDA5-mediated IFN-β-inducing potential
- 3A-18 Effect of methotrexate on ileal 5-hydroxy-tryptamine contents in ferrets
- The role of tumor necrosis factor-α for interleukin-10 production by murine dendritic cells
- GPI-アンカー型補体制御因子(CD59)のシグナル伝達機構
- Early postnatal stress affects 5-HT1A receptor function in the medial prefrontal cortex in adult rats
- Failure of mycoplasma lipoprotein MALP-2 to induce NK cell activation through dendritic cell TLR2
- Recombinant interleukin-12 and interleukin-18 antitumor therapy in a guinea-pig hepatoma cell implant model
- RNA interference (RNAi)を用いた哺乳類細胞での遺伝子ノックアウト
- Soluble G protein of respiratory syncytial virus inhibits Toll-like receptor 3/4-mediated IFN-beta induction
- The cytoplasmic 'linker region' in Toll-like receptor 3 controls receptor localization and signaling
- Toll-Like Receptor 3 : A Link between Toll-Like Receptor, Interferon and Viruses
- ウイルスによる1型インターフェロン誘導とTLR
- Docosahexaenoic Acid Enhances Cyclooxygenase-2 Induction by Facilitating p44/42, but Not p38, Mitogen-Activated Protein Kinase Activation in Rat Vascular Smooth Muscle Cells
- P6-04 New method to evaluate the drug-induced emesis : depolarization responses of isolated abdominal vagus nerve on rat and suncus murinus(LIVER AND DIGESTIVE SYSTEM/CIRCULATORY SYSTEM-1/DEVELOPMENT AND REPRODUCTION)(GENERAL SESSION BY POSTER PRESENTATIO
- S2-2 Anti-cancer drug-induced emesis(SYMPOSIUM 2: THE MECHANISMS INVOLVED IN EMESIS ASSOCIATED WITH VARIOUS DRUGS)(Proceedings of the 31st Annual Meeting)
- Cardiovascular Protective Effects of n-3 Polyunsaturated Fatty Acids With Special Emphasis on Docosahexaenoic Acid
- "P-62 Evaluation of anticancer drug-induced emesis by measurement of 5-hydroxytryptamine (5-HT) release from isolated ileum of ferrets and rats.
- "P-61 Effect of 5-hydroxytryptamine (5-HT)_4 receptor modulation on abdominal afferent vagal nerve activity in ferrets and rats.
- TOXICOLOGICAL ASPECTS OF CISPLATIN-INDUCED EMESIS WITH EMPHASIS ON SEROTONIN RELEASE
- MEASUREMENT OF ABDOMINAL AFFERENT VAGAL NERVE ACTIVITY TO ESTIMATE ANTICANCER DRUG-INDUCED EMESIS IN FERRETS AND RATS.
- THE PROTECTIVE EFFECT OF 4-HYDROXY-2-METHYL-N-[2-(TETRAZOL-5-YL)-PHENYL]-2H-1, 2-BENZOTHIAZINE-3-CARBOXAMIDE-1, 1-DIOXIDE MONOSODIUM SALT (HX-1920) ON CISPLATIN-INDUCED TOXICITY IN RATS
- 213 INCREASED TISSUE 5-HT CONCENTRATIONS OF THE AREA POSTREMA AND THE ILEUM DURING CYTOTOXIC DRUG-INDUCED EMESIS IN THE FERRET.
- EMESIS-RELATED BIOCHEMICAL AND HISTOPATHOLOGICAL CHANGES INDUCED BY CISPLATIN IN THE FERRET
- APPLICATION OF AUTOMATIC AMBULO-DRINKOMETER IN TOXICOLOGICAL STUDY
- CHANGES IN AMBULATORY AND DRINKING BEHAVIOR INDUCED BY CENTRALLY ACTING ANTIHYPERTENSIVE DRUGS IN SPONTANEOUSLY HYPERTENSIVE RATS
- 精子の受精レセプター, CD46のcDNAクローニング
- 補体C3活性化分子/細胞死関連分子M161抗原の局在とストレス応答
- HCVと自然免疫
- がんのアジュバント免疫療法の確立と開発
- マウスmembrane cofactor protein(CD46)のゲノム解析
- Pattern recognition receptors of innate immunity and their application to tumor immunotherapy
- Epstein-Barr virus (EBV)-encoded small RNA is released from EBV-infected cells and activates signaling from toll-like receptor 3
- Induction of NKG2D ligands on human dendritic cells by TLR ligand stimulation and RNA virus infection
- NK-activating dendritic cells are elicited by stimulation with Toll-like receptor 3
- Toll 様受容体の機能
- 樹状細胞パターン認識と関連分子のがんワクチンへの応用 (特集 がんワクチンの展望)
- 二重鎖RNA刺激に伴うTICAM-1/TRIFの細胞内動態 (特集 自然免疫におけるセンサーとそのシグナル伝達)
- 異種間ウイルス伝播における自然免疫の役割 : 麻疹ウイルス感染の成立における Type-I IFN の重要性
- Toll-like receptor (TLR) と抗ウィルス応答
- 社会問題-今科学は(23) : バイオデータマイニングのブレイクスルーDNAマイクロアレイのデータ解析を中心として
- Pathogen-associated molecular pattern(PAMP)と癌免疫
- Adjuvant engineering for cancer immunotherapy : Development of a synthetic TLR2 ligand with increased cell adhesion
- CHANGES OF HUMORAL AGENTS IN PHYSICAL EXERCISE BY BICYCLE ERGOMETER : IInd Auditorium : PROCEEDINGS OF THE 40TH ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
- EFFECTS OF FUROSEMIDE AND SOLUDACTONE ON OUABAIN TOXICITY IN GUINEA PIGS : IInd Auditorium : PROCEEDINGS OF THE 40TH ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
- The Kinase Complex Responsible for IRF-3-Mediated IFN-β Production in Myeloid Dendritic Cells (mDC)
- 麻疹ウイルスレセプターCD46 : 細胞内ドメインがウイルス高感受性を規定する
- Changes in Synaptic Properties in Cortical-Limbic Communications Induced by Repeated Treatments With Fluvoxamine in Rats
- Enhancement of antitumor natural killer cell activation by orally administered Spirulina extract in mice
- Ligation of Human CD46 with Purified Complement C3b or F(ab')_2 of Monoclonal Antibodies Enhances Isoform-Specific Interferon Gamma-Dependent Nitric Oxide Production in Macrophages
- Three Soluble Form Messages of Murine CD46 Are Produced through Alternative mRNA Splicing
- Molecular cloning and functional characterization of guinea pig IL-12
- ワクチン増強剤としての抗がんRNAアジュバントの展望 (特集 がんペプチドワクチンの実用化に向けて)
- Development of Mouse Hepatocyte Lines Permissive for Hepatitis C Virus (HCV)
- Effects of Acute Repetitive Transcranial Magnetic Stimulation on Extracellular Serotonin Concentration in the Rat Prefrontal Cortex
- -227-CHANGES OF HUMORAL AGENTS IN PHYSICAL EXERCISE BY TREADMILL : Exercise Cardiology : PROCEEDINGS OF THE 42nd ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
- 腫瘍浸潤myeloid cellsによる免疫抑制 (特集 腫瘍の免疫回避機構)
- Functional Interaction between Serotonin and Other Neuronal Systems: Focus on In Vivo Microdialysis Studies
- -91-CHANGES IN RENAL PROSTAGLANDIN SUBSTRATES IN SPONTANEOUSLY HYPERTENSIVE RATS
- Serotonin_ Receptor-Mediated Synaptic Response in the Rat Medial Prefrontal Cortex Is Altered by Early Life Stress : In Vivo and In Vitro Electrophysiological Studies
- 臨床 アジュバントを利用した樹状細胞の活性化と癌免疫療法への応用 (特集 樹状細胞--基礎と臨床)
- 補体C3活性化分子/細胞死関連分子, M161抗原に対するモノクローナル抗体の作製
- UNC93B1 Physically Associates with Human TLR8 and Regulates TLR8-Mediated Signaling
- DDX60, a DEXD/H Box Helicase, Is a Novel Antiviral Factor Promoting RIG-I-Like Receptor-Mediated Signaling
- Diazepam-Induced Increases of Synaptic Efficacy in the Hippocampal-Medial Prefrontal Cortex Pathway Are Associated With Its Anxiolvtic-like Effect in Rats
- 動物の自然免疫に於けるユビキチンリガーゼの役割 (特集 酵母から動植物まで包括するユビキチン-プロテアソーム系の新展開)
- ネクローシス細胞による炎症惹起の機序
- 自然免疫と癌治療 (第1土曜特集 自然免疫Update : 研究最前線) -- (自然免疫の関わる病態と治療への応用)
- RNAウイルス感染に対する自然免疫
- Ubiquitin-mediated modulation of the cytoplasmic viral RNA sensor RIG-I
- Possible Modulation of the Amygdala on Metaplasticity Deficits in the Hippocampal CA1 Field in Early Postnatally Stressed Rats
- Possible Modulation of the Amygdala on Metaplasticity Deficits in the Hippocampal CA1 Field in Early Postnatally Stressed Rats
- 動物の自然免疫に於けるユビキチンリガーゼの役割
- 微生物成分を用いたヒト樹状細胞の制御:Toll-like receptorによるPAMP認識とシグナル伝達 (特集 免疫細胞を用いた疾患の免疫制御)
- 自然免疫にかかわるToll-like receptor群の非自己認識機構
- TLR2アジュバントPam2リポペプチドの免疫抑制効果 : 制御性T細胞とIL-10誘導による抗腫瘍免疫抑制
- ラフトリンはウイルス二重鎖RNAの細胞内取り込みを誘導し, Toll-like receptor 3 活性化に必須の分子である
- TLR3/TICAM-1依存的経路はポリオウイルス感染時のI型インターフェロン産生に必須の役割を果たす
- RIG-I依存的なI型インターフェロン産生を誘導する新たな抗ウイルス分子DDX60ヘリケースの発見
- UNC93B1はヒトTLR8と相互作用し, TLR8を介したシグナル伝達を制御する
- C型肝炎ウイルスに感染するマウス肝細胞株の樹立
- ウイルス感染とToll-like receptor : Toll-like receptor 3によるウイルス dsRNA 認識
- TLRと抗がん免疫療法 (特集 Toll-like receptorの基礎と臨床)
- 補体系の自己-非自己識別の分子機構
- 補体制御因子と種間識別機構