EMESIS-RELATED BIOCHEMICAL AND HISTOPATHOLOGICAL CHANGES INDUCED BY CISPLATIN IN THE FERRET
スポンサーリンク
概要
- 論文の詳細を見る
Cisplatin is an effective antineoplastic agent that causes severe vomiting due to unknown mechanism. The ferret, an animal model useful in the determination of emetic activity, was used to clarify the emesis-related biochemical and histopathological changes that were induced by cisplatin. Cisplatin (5 to 10 mg/kg) was administered intraperitoneally and a 7-10 mg/kg i. p. dose evoked dose-dependent emesis in the ferret. Almost all cisplatin-vomiting episodes occurred within a 6 hour observation period. All ferrets receiving cisplatin in this study died within 3-5 days. Significant increases in ileal mucosal levels of serotonin and norepinephrine were observed in cisplatin-treated ferrets. There were no significant changes in the levels of serotonin and dopamine in the gastric mucosa. Also, karyorrhexis was observed in the epithelial cel1s of the ileum and in the lymph follicles of the spleen of cisplatin-treated ferrets. These significant biochemical and pathological changes in the ileum may play an important role in cisplatin-induced emesis.
- 日本トキシコロジー学会の論文
- 1990-11-26
著者
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Minami Masaru
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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Matsui Takane
United Graduate School Of Veterinary Sciences Gifu Unicersity
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Yoshioka Mitsuhiro
Facul.of Pharm.sci. Higashi-nippon-gakuen Univ. 1st Dept.of Pharmacol
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Monma Yoshio
Department Of Pharmacology School Of Medicine Hokkaido University:(present Address)department Of Pha
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Yoshioka Mitsuhiro
Hokkaido University Graduate School of Medicine
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SAITO Hideya
First Department of Pharmacology, Hokkaido University School of Medicine
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ENDO Toru
Department of Orthopedic Surgery, Wakayama Medical University
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Saito Hideya
Dept. Basic Sci. Jpn. Red Cross Hokkaido College Nursing:dept Pharmacol. Heallth Sci. Univ.
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Saito Hideya
Department Of Cardiovascular Medicine And Pharmacology. Hokkaido University
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Satoh H
Environmental Health Science Tohoku University Graduate School Of Medicine
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Saito Hideya
Dept. Of Pharm. School Of Med. Hokkaido Univ.
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Saito Hideya
First Department Of Pharmacology Hokkaido University School Of Medicine
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TAKEUCHI Masaya
Sapporo General Pathology Laboratory Co., LTD.
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Saito H
Tohoku Univ. Sendai
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Endo Toru
Dept. Basic Sci. Jpn. Red Cross Hokkaido College Nursing:dept Pharmacol. Heallth Sci. Univ.
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Endo Toru
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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Minami Masaru
Department Of Cardiovascular Medicine Hokkaido University School Of Medicine
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Minami M
Department Of Hygiene And Public Health Nippon Medical School
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Minami Masaru
Dep. Of Pharmacology Fac. Of Pharmaceutical Sciences Health Sciences Univ. Of Hokkaido
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Endo Toru
Department Of Chemistry Rikkyo University
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Takeuchi M
Safety Evaluation Drug Development Laboratories Pharmaceutical Research Division Yoshitomi Pharmaceu
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Monma Yoshio
Department Of Pharmacology And Toxitology Faculty Of Pharmaceutical Sciences
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Endo T
Laboratory For Toxicological Research Institute For Life Sciences Research Asahi Cheimical Industry
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Tezuka M
Nihon Univ. Chiba Jpn
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Endo Toru
Dept.of Pharmacol
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Takeuchi Masaki
Department Of Applied Chemistry Faculty Of Engineering Kanagawa University
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Makita Masaaki
Dept. Of Cardiovascular Med Hokkaido Univ.
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Monma Y
National Research Inst. Metals Tsukuba‐city Jpn
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Minami Masaru
Dept. Of Pharm. School Of Med. Hokkaido Univ.
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Satoh Hiroshi
Environmental Health Science Tohoku University Graduate School Of Medicine
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Endo Toru
Dept. Of Pharmacol. Facul. Of Pharm. Sci. Hlth Sci. Univ. Of Hokkaido
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Minami Masaru
Department Of Cardiovascular Medicine 1st Department Of Internal Medicine Hokkaido University School
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MONMA Yoshio
Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Higashi-Nippon-Gakuen University
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Saito Hideya
First Deparment of Pharmacology, Hokkaido University School of Medicine
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ENDO Toru
Department of Botany, University of Tokyo
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