EFFECT OF 4-PHENYL-1, 3-DITHIA-2-THIOXO-CYCLOPENT-4-ENE ON LIVER INJURY INDUCED BY REPEATED EXPOSURE TO GALACTOSAMINE PLUS CARBON TETRACHLORIDE IN RATS
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概要
- 論文の詳細を見る
The protective effects of 1, 3-dithia-2-thioxo-cyclopent-4-ene (DT827A), 4-phenyl-1, 3-dithia-2-thioxo-cyclopent-4-ene (DT827B) and 4-(4-fluorophenyl)-1, 3-dithia-2-thioxo-cyclopent-4-ene (DT827C) on liver injury induced by D-galactosamine plus carbon tetrachloride (D-GalN+CCl_4)and that of DT827B on liver injury induced by thioacetamide were studied using male rats. Out of the three DT827 series of compounds, DT827B was more effective on liver injury induced by the combination exposure to D-GaIN+CCl_4 for 4 weeks, and accordingly the following two experiments were carried out using DT827B only. Twelve-week administration of DT827B at dose levels of 5, 10 and 20 mg/kg/day revealed a therapeutic effect against liver injury induced by D-GaIN+CCl_4 dose-dependently, and another twelve-week administration of DT827B at the same three dose levels also revealed a therapeutic effect against liver injury induced by thioacetamide dose-dependently. A hepatoprotective potential of DT827B was suggested under the conditions of these studies.
- 日本トキシコロジー学会の論文
- 1998-05-09
著者
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Tezuka Masakatsu
Department of Hygienic Chemistry, College of Pharmacy, Nihon University
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TAKEUCHI Masaya
Sapporo General Pathology Laboratory Co., LTD.
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Takeuchi M
Safety Evaluation Drug Development Laboratories Pharmaceutical Research Division Yoshitomi Pharmaceu
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SADANOBU Shinro
Department of Hygienic Chemistry, College of Pharmacy, Nihon University
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Tezuka M
Nihon Univ. Chiba Jpn
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Takeuchi Masaki
Department Of Applied Chemistry Faculty Of Engineering Kanagawa University
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Tezuka Masakatsu
Department Of Health Science College Of Pharmacy Nihon University
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Sadanobu S
Nihon Univ. Chiba Jpn
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Sadanobu Shinro
Department Of Hygienic Chemistry College Of Pharmacy Nihon University
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