LARGE AMOUNT OF VITAMIN A HAS NO MAJOR EFFECTS ON THYROIDAL HORMONE SYNTHESIS IN TWO-STAGE RAT THYROID CARCINOGENESIS MODEL USING N-BIS(2-HYDROXYPROPYL)NITROSAMINE AND THIOUREA
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概要
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In our previous investigation, which focused on two-stage carcinogenicity in the thyroid, rats were administered N-bis(2-hydroxypropy1)nitrosamine(DHPN), followed by thiourea(TU)over an experimental period of 19 weeks. Simultaneous treatment with a high level of vitamin A(VA)enhanced the induction of proliferative lesions that originated from the thyroidal follicular epithelium. To examine whether hormone synthesis in the thyroid could be inhibited by simultaneous treatment with a large amount of VA and TU, all of the rats were initially given a single subcutaneous injection of 2, 800 mg DHPN / kg followed by a supply of 0% TU+0% VA(DHPN only, control group), 0.2% TU in their drinking water(DHPN / TU group), 0.1% VA in their diet(DHPN / VA group), or 0.2% TU+0.1% VA(DHPN / TU+VA group)during an experimental period of 4 weeks. Results obtained indicate that the iodine uptake and organification, namely iodination of tyrosine residue in thyroglobulin, of the thyroid, were significantly decreased in the DHPN / TU group compared to the DHPN control group. The variation in these values was attributable to the inhibitory effect of TU upon thyroid hormone synthesis. Results obtained from the DHPN / TU+VA and DHPN / TU groups were comparable. Therefore, the possibility that modification of hormone synthesis contributes to the enhancing effect of simultaneous treatment with a large amount of VA on thyroidal tumor induction by TU is considered to be very minimal.
- 日本トキシコロジー学会の論文
- 2000-05-11
著者
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高橋 通正
(独)産業技術総合研究所 環境管理技術研究部門
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YANAI Tokuma
Department of Veterinary Pathology, Gifu University
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MASEGI Toshiaki
Department of Veterinary Pathology, Gifu University
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MITSUMORI Kunitoshi
Division of Pathology, National Institute of Health Sciences
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YAMADA Tomoya
Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd.
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Takegawa Kiyoshi
Division of Pathology, National Institute of Health Sciences
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Takegawa K
Division Of Pathology National Institute Of Health Sciences:safety Evaluation Drug Development Labor
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Takegawa Kiyoshi
三菱ウェルファーマ
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Takada Koichi
Safety Evaluation Laboratory Yoshitomi Pharmaceutical Industries Co. Ltd.
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Takegawa K
Toxicology Laboratories Pharmaceutical Research Division Mitsubishi Pharma Corporation
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Takegawa Kiyoshi
Department Of Pathology National Institute Of Health Sciences
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Takegawa Kiyoshi
Safety Evaluation Drug Development Laboratories Pharmaceutical Research Division Yoshitomi Pharmaceu
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Takada Koichi
国立医薬品食品衛生研究所
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Mitsumori Kunitoshi
Division Of Pathology National Institute Of Health Sciences
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Takagi Shiro
Safety Evaluation Laboratory Yoshitomi Pharmaceutical Industries Co. Ltd.
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Takagi Shiro
Research Laboratories Yoshitomi Pharmaceutical Industries
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Takagi Shiro
Drug Discovery Laboratories Pharmaceutical Research Division Welfide Co.
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Yanai Tokuma
Department Of Veterinary Pathology Faculty Of Agriculture Gifu University
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TAKEUCHI Masaki
Safety Evaluation Department, Yoshitomi Pharmaceutical Industries Ltd.
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Takada Koichi
Division Of Toxicology Biological Safety Research Center National Institute Of Health Sciences
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SAKAMORI Masamitsu
Safety Evaluation Laboratory, Yoshitomi Pharmaceutical Industries Co., Ltd.
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KOREMOTO Megumi
Safety Evaluation Laboratory, Yoshitomi Pharmaceutical Industries Co., Ltd.
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YAMADA Tsuneyo
Safety Evaluation Laboratory, Yoshitomi Pharmaceutical Industries Co., Ltd.
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Takada Koichi
Dept. Of Toxicology Bioological Safety Research Center National Institute Of Hygienic Sciences
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Sakamori Masamitsu
Safety Evaluation Laboratory Yoshitomi Pharmaceutical Industries Co. Ltd.
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Takada Kouichi
Division Of Toxicology Biological Safety Research Center National Institute Of Health Sciences
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Yamada T
Environmental Health Science Laboratory Sumitomo Chemical Co. Ltd.
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Yamada Tsuneyo
Safety Evaluation Laboratory Yoshitomi Pharmaceutical Industries Co. Ltd.
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Takeuchi M
Safety Evaluation Drug Development Laboratories Pharmaceutical Research Division Yoshitomi Pharmaceu
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Yanai T
United Graduate School Of Veterinary Sciences Gifu University
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Matsumoto K
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
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Takada Koichi
Divisions Of Toxicology National Institute Of Hygienic Sciences
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Tezuka M
Nihon Univ. Chiba Jpn
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Takeuchi Masaki
Department Of Applied Chemistry Faculty Of Engineering Kanagawa University
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Masegi Toshiaki
Department Of Veterinary Pathology Faculty Of Agriculture Gifu University
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Takada Koichi
Division Of Toxicology Biological Safety Research Center National Institute Of Hygienic Sciences
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Takada Koichi
吉富製薬福崎安全性研究所
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Koremoto Megumi
Safety Evaluation Laboratory Yoshitomi Pharmaceutical Industries Co. Ltd.
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Masegi Toshiaki
Department Of Gastroenterology And Metabolism Nagoya City University Graduate School Of Medical Scie
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YANAI Tokuma
Department of Pathogenetic Veterinary Sciences, United Graduate School of Veterinary Sciences, Gifu University, 1–1 Yanagido, Gifu 501–1193, Japan
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