Significant Factors on Gastric Carcinogenesis Revealed by Experimental Animal Models

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概要

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• The pathological and molecular biochemical analyses in the experimental animal models are important for the solutions of human disorders, including stomach cancer. Stomach cancers are induced experimentally by N-methyl-N-nitro-N-nitrosoguanidine (MNNG) and N-methyl-N-nitrosourea (MNU) in rats and mice. Helicobacter pylori (H. pylori) is one of the most important factor in the human stomach disorders, and the H. pylori infected and chemical carcinogen treated Mongolian gerbil (MG) has thus proved very useful for the analysis of human stomach carcinogenesis. Intestinal metaplasia is important not as a precancerous lesion but as a paracancerous cord from such studies of clonality of stomach cancers and of phenotypic expression of each intestinal metaplastic or stomach cancer cell, while the pepsinogen altered pyloric glands can be regarded as a common change in rodents, acting as a precursor for a variety of adenocarcinoma types. As the results of the analyses of the MG model, H. pylori is a strong promoter of gastric carcinogenesis rather than an initiator. The dose-dependent enhancing effects of salt on stomach carcinogenesis are demonstrated in the MGs treated with MNU and H. pylori, although high salt intake has a minor influence compared to H. pylori. Bile reflux is not an initiator, but rather an important promoter in the carcinogenesis of gastric stump after partial gastrectomy. Stomach cancers develop from single cells, based on data from clonality analysis in C3H/HeN⇔BALB/c chimeric mice. Intestinalization progresses from gastric, through gastric-and-intestinal mixed, to intestinal phenotypes in non-cancerous and cancerous tissue independently. The chemopreventive effects of H. pylori eradication and reduction of salt intake against stomach cancer are confirmed in the MG models.

• 日本毒性病理学会の論文
• 2006-06-01

著者

• 高橋 通正

  (独)産業技術総合研究所 環境管理技術研究部門

• Tatematsu M

  Division Of Oncological Pathology Aichi Cancer Center Research Institute

• Tsukamoto T

  Division Of Oncological Pathology Aichi Cancer Center Research Institute

• TSUKAMOTO Tetsuya

  Division of Oncological Pathology, Aichi Cancer Center Research Institute

• TATEMATSU Masae

  Division of Oncological Pathology, Aichi Cancer Center Research Institute

• MIZOSHITA Tsutomu

  Division of Oncological Pathology, Aichi Cancer Center Research Institute

• Takahashi M

  National Inst. Health Sci. Tokyo

• Tatematsu Masae

  Division Of Oncological Pathology Aichi Cancer Center Research Institute

• Tatematsu M

  愛知県がんセンター研究所 腫瘍病理学部

• Tsukamoto Tetsuya

  Division Of Oncological Pathology Aichi Cancer Center Research Institute

• Tatematsu Masae

  愛知県がんセンター研究所 腫瘍病理学部

• Taniyama T

  Okayama Univ. Okayama

• Takaoka Masaya

  Medicinal Safety Research Laboratories Daiichi-sankyo Co. Ltd.

• Tsukamoto Takahisa

  First Department Of Oral And Maxillofacial Surgery School Of Dentistry

• Mizoshita Tsutomu

  Department Of Gastroenterology And Metabolism Nagoya City University Graduate School Of Medical Scie

• Mizoshita Tsutomu

  Division Of Oncological Pathology Aichi Cancer Center Research Institute

• Tsukamoto Takahisa

  Division Of Oncological Pathology Aichi Cancer Center Research Institute

• Takato T

  Division Of Oncological Pathology Aichi Cancer Center Research Institute

• Taniyama Tetsuhide

  First Department Of Oral And Maxillofacial Surgery School Of Dentistry

• Tsukamoto T

  Department Of Public Health Osaka City University Graduate School Of Medicine

• Makita Takashi

  Dept. Vet. Anat. Yamaguchi Univ.

• Maejima Takanori

  Medicinal Safety Research Laboratories Sankyo Co. Ltd.

• TOGE TETSUYA

  Division of Oncological Pathology, Aichi Cancer Center Research Institute

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