Evaluation of Cell Proliferation in Canine Tumors by the Bromodeoxyuridine Labeling Method, Immunostaining of Ki-67 Antigen and Proliferating Cell Nuclear Antigen
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概要
- 論文の詳細を見る
Cell proliferation activity and correlation between the LI (labeling index) of BrdU (5-bromo-2-deoxy-uridine) and the expression of the Ki-67 antigen or PCNA (proliferating cell nuclear antigen) were evaluated by immunohistochemistry in 18 canine spontaneous neoplasms. Spearmans rank correlation coefficient and linear regression analysis revealed a significant correlation between the BrdU LI and Ki-67 LI, BrdU LI and PCNA LI, and BrdU LI and MI (mitotic index) in each case [rs = 0.917, P < 0.01 (BrdU LI vs. Ki-67 LI), rs = 0.736, P < 0.01 (BrdU LI vs. PCNA LI), rs = 0.748, P < 0.01 (BrdU LI vs. MI) by Spearmans rank correlation coefficient; and r = 0.918, P < 0.01 (BrdU LI vs. Ki-67 LI), r = 0.626, P < 0.01 (BrdU LI vs. PCNA LI), r = 0.763, P < 0.01 (BrdU LI vs. MI) by linear regression analysis]. Ki-67 LIs were more closely correlated with BrdU LIs than PCNA LIs or MIs, and the Ki-67 antigen is useful as an endogenous proliferation marker in canine neoplasms.
- 日本毒性病理学会の論文
- 2006-09-30
著者
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高橋 通正
(独)産業技術総合研究所 環境管理技術研究部門
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Tatematsu M
Division Of Oncological Pathology Aichi Cancer Center Research Institute
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SAKAI Hiroki
Laboratory of Oncological Pathology, Aichi Cancer Center Research Institute
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Takahashi M
National Inst. Health Sci. Tokyo
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坂井 宏明
帯広畜産大学畜産学部獣医学科家畜内科学教室
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YANAI Tokuma
Laboratory of Veterinary Pathology, Faculty of Applied Biological Sciences, Gifu University
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高橋 通正
神奈川県環境科セ
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MASEGI Toshiaki
Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Faculty of Applied Biological
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Yanai T
Department Of Veterinary Pathology Gifu University
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Totsuka Yukari
大阪府立大学先端科学イノベーションセンター 遺伝子環境科学研究室
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Totsuka Y
Cancer Prevention Basic Research Project
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Tatematsu M
愛知県がんセンター研究所 腫瘍病理学部
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高岡 雅哉
Medicinal Safety Research Laboratories Daiichi-sankyo Co. Ltd.
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Tatematsu Masae
愛知県がんセンター研究所 腫瘍病理学部
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Yamachika Takasuke
Division Of Oncological Pathology Aichi Cancer Center Research Institute
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Tajika Masahiro
Department Of Gastroenterology Aichi Cancer Center Hospital
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Takaoka Masaya
Medicinal Safety Research Laboratories Daiichi-sankyo Co. Ltd.
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ISHIKAWA Katsuyuki
Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Faculty of Applied Biological
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HOSOI Masayo
Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Faculty of Applied Biological
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Makino Toshihiko
Medicinal Safety Research Laboratories Daiichi Sankyo Co. Ltd.:department Of Veterinary Pathology Gr
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Hosoi Masayo
Laboratory Of Veterinary Pathology Department Of Veterinary Medicine Faculty Of Applied Biological S
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Mizoshita Tsutomu
Department Of Gastroenterology And Metabolism Nagoya City University Graduate School Of Medical Scie
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Sakai Hiroki
Laboratory Of Biological Chemistry Department Of Chemistry Faculty Of Science Hokkaido University
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Totsuka Yukari
国立がん研究センター研究所 発がんシステム研究分野
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Ishikawa Katsuyuki
Laboratory Of Veterinary Pathology Department Of Veterinary Medicine Faculty Of Applied Biological S
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Makita Takashi
Dept. Vet. Anat. Yamaguchi Univ.
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Makita Takashi
Medicinal Safety Research Laboratories Daiichi Sankyo Co. Ltd.:department Of Veterinary Pathology Gr
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YANAI Tokuma
Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University
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