Characteristics of Circadian Gene Expressions in Mice White Adipose Tissue and 3T3-L1 Adipocytes
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概要
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Most, if not all, of physiological and behavioral processes exhibit circadian rhythms. Recently, molecular clocks similar to those operating in the suprachiasmatic nucleus (SCN) neurons have been found in several peripheral tissues. Among peripheral tissues, several recent studies have revealed that white adipose tissues secrete a number of biologically active molecules such as leptin, resistin, adiponectin, etc. Importantly, the levels of these cytokine-like molecules are associated with development of lifestyle-related diseases such as diabetic mellitus, cardiovascular diseases, and obesity. In this study, we attempted to characterize circadian gene expression in adipose tissue. Here, we show that the expression of several clock genes exhibits daily oscillation in mice white adipocytes. Circadian expression of adipocytes-related genes such as peroxisome proliferator-activated receptor (PPAR) _γ2 was also observed. Interestingly, expression pattern of some clock genes in adipocytes is distinct from that in stromal-vascular fractions containing preadipocytes. In addition to these in vivo studies, we demonstrated that serum- or dexamethasone-shock induced the cyclic gene expression of clock genes in cultured adipocytes. Consequently, we are led to conclude that adipocytes contain the machineries necessary for circadian oscillation similar to that found in SCN. We then examined that whether the pharmacological effects of PPAR_γ2 ligand depend on the time of administration. Consist with its receptor levels, the pharmacological effects of PPAR_γ ligand administered during a dark period were more efficient than those during a light period in mice. These results suggest that chronotherapy targeted for adipocyte functions could be effective in improving of the symptoms of hyperlipidemia and other related diseases.
- 公益社団法人日本薬学会の論文
- 2005-02-01
著者
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Shimba S
Department Of Radiobiochemistry School Of Pharmaceutical Sciences University Of Shizuoka
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Shimba Shigeki
日本大学 薬学部衛生化学
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Shimba S
Nihon Univ. Chiba Jpn
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Shimba Shigeki
Department Of Hygienic Chemistry College Of Pharmacy Nihon University
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Shimba Shigeki
Department Of Health Science College Of Pharmacy Nihon University
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Tezuka Masakatsu
Department of Hygienic Chemistry, College of Pharmacy, Nihon University
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Aoyagi Toshinori
Department of Health Science, College of Pharmacy, Nihon University
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Aoyagi Toshinori
Department Of Health Science College Of Pharmacy Nihon University
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Takeuchi M
Safety Evaluation Drug Development Laboratories Pharmaceutical Research Division Yoshitomi Pharmaceu
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Tezuka M
Nihon Univ. Chiba Jpn
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Takeuchi Masaki
Department Of Applied Chemistry Faculty Of Engineering Kanagawa University
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Tezuka Masakatsu
Department Of Health Science College Of Pharmacy Nihon University
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