ENHANCEMENT OF ANTITUMOR ACTIVITY OF 5-FLUOROURACIL BY RIBOTHYMIDINE
スポンサーリンク
概要
- 論文の詳細を見る
The antitumor activity of 5-fluorouracil (5-FU) in combination with ribothymidine was examined on some experimental murine carcinomas. The antitumor activity of 5-FU against Ehrlich ascites carcinoma was markedly enhanced by intraperitoneal coadministration of ribothymidine. The enhancement of the antitumor activity of 5-FU by ribothymidine was also observed against Ehrlich solid carcinoma both by oral and intraperitoneal administrations. Furthermore, the combination therapy of 5-FU and ribothymidine was effective even on 5-FU-resistant P388 leukemia. These results suggest that the combination of 5-FU and ribothymidine may be more effective than 5-FU monotherapy in clinical use.
- 公益社団法人日本薬学会の論文
著者
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Okada S
Tokyo Medical Univ. Tokyo
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Okada S
Univ. Shizuoka Shizuoka Jpn
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Chiba Yoshiyuki
Department of Neurosurgery, Kobe University Graduate School of Medicine
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Tamemasa O
Shizuoka Coll. Pharmacy Shizuoka‐shi Jpn
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Tamemasa Osamu
Department Of Pharmacy Niigata University School Of Medicine
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Tezuka M
Department Of Health Science College Of Pharmacy Nihon University
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Tezuka Masakatsu
Department Of Health Science College Of Pharmacy Nihon University
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Okada Shoji
Department Of Environmental Biochemistry Shizoka College Of Pharmacy
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Chiba Yoshiyuki
Department Of Radiobiochemistry Shizuoka College Of Pharmacy
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Chiba Yoshiyuki
Department Of Dermatology Yokohama City University School Of Medicine
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Okada Shoji
Department of Chemistry, Faculty of Science and Technology, Kinki University
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