Influence of Histidine on Zinc Transport into Rat Brain

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概要

• 論文の詳細を見る

• The brain of rats injected intravenously with ^<65>Zn-His or ^<65>ZnCl_2 was subjected to autoradiography to study the role of histidine on zinc transport into the brain. One hour after injection, the radioactivity from ^<65>Zn-His was largely concentrated in the choroid plexus in the ventricles. Six days after injection, the radioactivity from ^<65>Zn-His was relatively concentrated in the hippocampal CA3 and dentate gyrus and the amygdala. The relative distribution of ^<65>Zn-His in the brain was similar to that of ^<65>ZnCl_2 group at both 1 h and 6 days, suggesting that histidine may participate in zinc uptake in the brain. Oh the other hand, the clearance of the ^<65>Zn-His group from the blood was higher than that of the ^<65>ZnCl_2 group. Brain uptake of the former was lower than that of the latter both 1 h and 6 days after injection. These results suggest that zinc uptake in the brain is influenced by histidine levels in the bloodstream.

• 公益社団法人日本薬学会の論文
• 2000-06-01

著者

• TAKEDA Atsushi

  Department of Computer Science, Tohoku Bunka Gakuen University

• OKU Naoto

  Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka

• 奥 直人

  Dep. Of Medical Biochemistry School Of Pharmaceutical Sciences Univ. Of Shizuoka

• Oku Naoto

  静岡県立大学 薬学部

• Oku N

  Univ. Shizuoka Shizuoka Jpn

• Okada Shoji

  Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka

• Oku Naoto

  Department Of Medical Biochemistry And Coe Program In The 21st Century University Of Shizuoka School

• Okada S

  Department Of Medical Biochemistry School Of Pharmaceutical Sciences University Of Shizuoka

• Okada S

  Department Of Radiobiochemistry School Of Pharmaceutical Sciences University Of Shizuoka

• Okada S

  Tokyo Medical Univ. Tokyo

• Okada S

  Kumamoto Univ. Kumamoto Jpn

• Okada S

  Univ. Shizuoka Shizuoka Jpn

• Okada Shoji

  Department Of Environmental Biochemistry Shizuoka College Of Pharmacy

• Takeda A

  Univ. Shizuoka Shizuoka Jpn

• Suzuki Mai

  Department of Pathology, Fujita Health University School of Medicine

• Suzuki Mai

  Department Of Radiobiochemistry School Of Pharmaceutical Sciences University Of Shizuoka

• Suzuki Mai

  Department Of Applied Physics And Chemistry The University Of Electro-communications

• 奥 直人

  静岡県立大学薬学部医薬生命科学教室

• Takeda Atsushi

  Department Of Clinical Pathology Showa University Fujigaoka Hospital Showa University School Of Medi

• Okada Shoji

  Department Of Environmental Biochemistry Shizoka College Of Pharmacy

• TAKEDA Atsushi

  Department of Clinical Pathology Showa University Fujigaoka Hospital

• OKU Naoto

  Department of Biochemistry, Faculty of Pharmaceutical Sciences, Setsunan University

• Okada Shoji

  Department of Chemistry, Faculty of Science and Technology, Kinki University

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