Skin Whitening Effect of Linoleic Acid Is Enhanced by Liposomal Formulations (Biopharmacy)
スポンサーリンク
概要
- 論文の詳細を見る
Linoleic acid (LA) is known to have a whitening effect on hyperpigmented skin, and is encapsulated in liposomes for topical application because of its low solubility in aqueous solution, although the effect of liposomalization of LA on the whitening activity has not been evaluated. In the present study, we evaluated the effect of liposomalization on the whitening activity of LA by using LA in ethanol, hydrogel containing LA, and hydrogel containing liposomal LA towards the UV-stimulated hyperpigmented dorsal skin of brownish guinea pigs. The whitening effect was far greater for hydrogel containing liposomal LA (0.1% w/w as a final concentration of LA) than for free LA in ethanol or hydrogel containing LA. Next, the whitening effect of LA was examined with UV-stimulated hyperpigmented human upper arm skin by using a hydrogel containing liposomal LA (0.1% LA) and non-liposomal LA (3.0, 10.0% LA). Liposomal LA (0.1%) showed a whitening effect comparable to 10.0% nonliposomal LA and was far more effective than 3.0% non-liposomal LA. These results indicate that liposomal formulations are favorable for the transdermal application of LA.
- 公益社団法人日本薬学会の論文
- 2004-04-01
著者
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OKU Naoto
Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka
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奥 直人
Dep. Of Medical Biochemistry School Of Pharmaceutical Sciences Univ. Of Shizuoka
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Oku Naoto
静岡県立大学 薬学部
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奥 直人
静岡県立大学 薬学部 医薬生命化学教室
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Oku N
Univ. Shizuoka Shizuoka Jpn
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IMANAKA Hiromichi
R&D Center, Sunstar Inc.
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MAKINO Taketoshi
R&D Center, Sunstar Inc.
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Oku Naoto
Department Of Medical Biochemistry And Coe Program In The 21st Century University Of Shizuoka School
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Baba N
Graduate School Of Natural Science And Technology Okayama University
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Baba Naomichi
Department Of Bioresources Chemistry Faculty Of Agriculture Okayama University
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Baba Naomichi
Department Of Biore Sources Chemistry Faculty Of Agriculture Okayama University
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Shigeta Yasutami
Department of Bioresources Chemistry, Faculty of Agriculture, Okayama University
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ANDO Hideya
R&D Center, SUNSTAR Inc.
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RYU Atsuko
R&D Center, SUNSTAR Inc.
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Makino Taketoshi
R&d Division Sunstar Inc.
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Imanaka Hiromichi
Department Of Medical Biochemistry Graduate School Of Pharmaceutical Sciences University Of Shizuoka
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Ryu Atsuko
R&d Center Sunstar Inc.
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Baba Naomichi
Div. Of Bioscience Graduate School Of Natural Sci. And Technol. Okayama Univ.
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Makino T
Department Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Kyoto University
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奥 直人
静岡県立大学薬学部医薬生命科学教室
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Makino Toshiaki
R&d Division Sunstar Inc.
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Shigeta Y
Department Of Bioresources Chemistry Faculty Of Agriculture Okayama University:r&d Center Sunsta
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Shigeta Yasutami
Department Of Bioresources Chemistry Faculty Of Agriculture Okayama University
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BABA Naomichi
Department of Biofunctional Chemistry, Graduate School of Natural Science and Technology, Okayama University
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OKU Naoto
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Setsunan University
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