β-Thujaplicin Zinc Chelate Induces Apoptosis in Mouse High Metastatic Melanoma B16BL6 Cells

スポンサーリンク

概要

• 論文の詳細を見る

• The cytotoxic effects of β-thujaplicin and five kinds of metal chelates were examined on mouse melanoma B16BL6 cells by cell viability and lactate dehydrogenase (LDH) release assay. β-Thujaplicin-zinc chalate and β-thujaplicin-copper chelate had higher cytotoxic effects than β-thujaplicin, and the 50% effective does (ED_<50>) of these metal chelates were 12.5 and 25 μM, respectively. In addition, the zinc chelate induced DNA ladder formation in B16BL6 cells, as shown by the DNA fragmentation assay, suggesting that cell death induced by the zinc chelate is apoptosis. The zinc chelate also had a cytotoxic effect and induced DNA fragmentation on other tumor cell lines : HeLa, Meth A, and B16F1 cells, but not on normal human diploid fibroblasts FS-4. These results suggest that β-thujaplicin-zinc chelate induces apoptotic cell death in various tumor cell lines and is a potent antitumor agent for tumor cells including malignant melanomas.

• 社団法人日本薬学会の論文
• 1998-12-15

著者

• SUZUKI Takashi

  Department of Biochemistry, University of Shizuoka, School of Pharmaceutical Sciences, Core Research

• MIYAMOTO Daisei

  Department of Biochemistry, University of Shizuoka, School of Pharmaceutical Sciences, Core Research

• SUZUKI Yasuo

  Department of Biochemistry, University of Shizuoka, School of Pharmaceutical Sciences, Core Research

• OKU Naoto

  Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka

• 奥 直人

  Dep. Of Medical Biochemistry School Of Pharmaceutical Sciences Univ. Of Shizuoka

• Oku Naoto

  静岡県立大学 薬学部

• Suzuki Y

  School Of Pharmaceutical Sciences University Of Shizuoka

• Suzuki Y

  Fukuoka Inst. Technol. Fukuoka

• Suzuki T

  Department Of Biochemistry University Of Shizuoka School Of Pharmaceutical Sciences:core Research Fo

• Oku Naoto

  Department Of Medical Biochemistry And Coe Program In The 21st Century University Of Shizuoka School

• Suzuki Y

  Department Of Pharmacobiology And Therapeutics Faculty Of Pharmacy Meijo University

• Suzuki Y

  Core Research For Evolutional Science And Technology (crest Jst) University Of Shizuoka School Of Ph

• ENDO Naoko

  Department of Biochemistry University of Shizuoka, School of Pharmaceutical Sciences

• Endo N

  Department Of Biochemistry University Of Shizuoka School Of Pharmaceutical Sciences

• Miyamoto Daisei

  Department Of Biochemistry University Of Shizuoka School Of Pharmaceutical Sciences:core Research Fo

• Suganuma Taiyo

  (pressent Address)department Of Pharmacology Tokyo Women's Medical University

• 奥 直人

  静岡県立大学薬学部医薬生命科学教室

• Suzuki Takashi

  Department Of Biochemistry University Of Shizuoka School Of Pharmaceutical Sciences:core Research Fo

• Arima Yaeno

  Dep. Of Dermatology Kyoto Univ. Graduate School Of Medicine

• Suzuki Y

  Department Of Pharmacology Faculty Of Pharmacy Meijo University

• Suzuki Yasuo

  Department Of Applied Physics Faculty Of Engineering Fukui University

• Suzuki Takashi

  Department Of Anesthesia Showa University Northern Yokohama Hospital

• Suzuki Takashi

  Department Of Anatomic Pathology Tohoku University School Of Medicine

• OKU Naoto

  Department of Biochemistry, Faculty of Pharmaceutical Sciences, Setsunan University

関連論文

• Distribution of Influenza Virus Sialoreceptors on Upper and Lower Respiratory Tract in Horses and Dogs
• Identification and Characterization of Carbohydrate Molecules in Mammalian Cells Recognized by Dengue Virus Type 2
• A Unique Phosphatidylinositol Bearing a Novel Branched-Chain Fatty Acid from Rhodococcus equi Binds to Influenza Virus Hemagglutinin and Inhibits the Infection of Cells
• lnhibitory action of sulfatide a putative ligand for L-selectiv on B cell proliferation and lg prodrction
• Thermodynamic and Transport Properties of CeMg_2Cu_9 under Pressure(Condensed Matter : Electronic Structure, Electrical, Magnetic and Optical Properties)
• The odontoblast as a sensory receptor cell? The expression of TRPV1 (VR-1) channels
• Sex steroid receptors expression and hormone-induced cell proliferation in human osteosarcoma
• INTRADUCTAL ULTRASONOGRAPHY BEFORE BILIARY DRAINAGE AND TRANSPAPILLARY BIOPSY IN ASSESSMENT OF THE LONGITUDINAL EXTENT OF BILE DUCT CANCER
• Amylase levels in bile in patients with a morphologically normal pancreaticobiliary ductal arrangement
• Clinicopathological study on the intraductal spread of small pancreatic cancer
• DIAGNOSIS OF GASTRIC MUCINOUS CARCINOMA BY ENDOSCOPIC ULTRASONOGRAPHY
• HANDMADE OUTER FLUSHING CHANNEL FOR SAFE ENDOSCOPIC SUBMUCOSAL DISSECTION
• Superconductivity in Th_3Ni_3Sn_4
• Temperature Dependence of the Yb 4f Spectra in Yb_4Bi_3 Probed by Photoemission Spectroscopy
• XPS and X-BIS Studies of Gd Monopnictides
• Correlation between superconductivity and in-plane resistivity in La_Sr_xCuO_4(Condensed Matter : Electronic Structure, Electrical, Magnetic and Optical Properties)
• Unconventional Strain Dependence of Superconductivity in Spin-Triplet Superconductor Sr_2RuO_4
• In Vitro Inhibition of Human Influenza A Virus Infection by Fruit-Juice Concentrate of Japanese Plum (Prunus mume SIEB. et ZUCC)(Microbiology)
• Clarithromycin Inhibits Progeny Virus Production from Human Influenza Virus-Infected Host Cells(Microbiology)
• Suppression of the Biosynthesis of Cellular Sphingolipids Results in the Inhibition of the Maturation of Influenza Virus Particles in MDCK Cells(Highlighted paper selected by Editor-in-chief,Biochemistry)
• In Vitro and in Vivo Inhibitory Effects of Disodium Cromoglycate on Influenza Virus Infection(Pharmacology)
• Duck and Human Pandemic Influenza A Viruses Retain Sialidase Activity under Low pH Conditions^1
• Ganglioside GM_ on the Cell Surface Is Involved in the Infection by Human Rotavirus KUN and MO Strains
• Structural Transitions and Localization in La_Nd_ySr_xCuO_4 With p〜1/8
• Different Electronic Ground States in the Hexagonal and Cubic Phases of UAu_2Sn
• The Origin of Magnetic Field Dependence of Specific Heat in Single-Crystalline CeNiSn
• Huge Lattice Softening in CeRu_2 without Structural Transition
• Neutron Diffraction Study of the Magnetic Ordering of Low Carrier Kondo Lattice System CeAs under High Pressure
• High Pressure Studies on Electrical and Magnetic Properties of Ce-monopnictides, and Some Other Ce and U Compounds : Chapter 6. Magnetic Properties : 6-1. Measurements under Extreme Conditions
• Pressure-Induced Electronic Phase Transition in CeP
• High Resolution 4d-4f Resonance Photoemission Spectroscopy of CePdX (X=As,Sb)
• Temperature-Dependent Change of Correlated Electronic States in Yb_4As_3 and Yb_4(As_Sb_x)_3 Probed by High Resolution Photoemission Spectroscopy
• Crystal-field *_8-like State in Magnetically Ordered Phases of CeP : Its Anisotropy and Influence on Electronic Structure via High-Field Magnetotransport Measurements
• Core Photoemission Spectra of U_3P_4 and U_3As_4 Single Crystals
• Elastic, Thermal, Magnetic and Transport Properties of Kondo Compounds CeRhIn and CeRhSn(Condensed Matter : Electronic Structure, Electrical, Magnetic and Optical Properties)
• Immunohistochemistry of a Proliferation Marker Ki67/MIB1 in Adrenocortical Carcinomas : Ki67/MIB1 Labeling Index Is a Predictor for Recurrence of Adrenocortical Carcinomas
• Optical Study on Heavy Fermion and Mixed Valence in Yb_4As_3
• Magnetic Polaron of Gd_2S_3 Studied by Infrared Spectroscopy under Magnetic Field
• Optical Study of Electronic Structure and Nonmetal-Metal Transition of Gd_2S_3
• de Haas-van Alphen Effect and Fermi Surface of USb
• Low Energy Excitations in the Low-Carrier Heavy-Electron System Yb_4As_3
• Divalent State in YbGaGe : Magnetic, Thermal, Transport and Structural Studies(Condensed Matter : Electronic Structure, Electrical, Magnetic and Optical Properties)
• Divalent State in YbGaGe : Magnetic, Thermal, Transport and Structural Studies
• Dielectric Dispersion of Valence Fluctuation Compound Sm_3Se_4
• Low Temperature Properties of the Magnetic Semiconductor TmTe
• Thermoosmosis Across Hydrophobic and Hydrophilic Polymer Membranes
• Thermoosmosis and Transported Entropy of Water across Hydrocarbonsulfonic Acid-Type Cation-Exchange Membranes
• A Case of Aldosterone-Producing Adrenocortical Adenoma Associated with a Probable Post-Operative Adrenal Crisis : Histopathological Analyses of the Adrenal Gland
• Retinoic Acid Receptor and Retinoid X Receptor in Ductal Carcinoma in situ and Intraductal Proliferative Lesions of the Human Breast
• PE-312 Endothelial Cell-derived Endothelin-1 Regulates Proteinuria and Glomerular Barrier Function in Diabetic Mice(PE053,Peripheral Circulation/Vascular Disease (Therapy), Kidney/Renal Circulation/CKD (H),Poster Session (English),The 73rd Annual Scientif
• 1 Endothelial Cell-derived Endothelin-1 Promotes Cardiac Fibrosis in Diabetic Heart through Stimulation of Endothelial to Mesenchymal Transition(Young Investigator's Award for International Students Finalists Lecture (YIA International),The 73rd Annual Sc
• OE-223 Genetic Inactivation of Vascular Endothelial Cell Endothelin-1 in Mice is Protective against Diabetic-Induced Renal Injury(Kidney/Renal circulation(01)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Soc
• OE-139 Preservation of Cardiac Function in Diabetic Mice with Specific Knockout of Endothelin-1 in Vascular Endothelial Cell(Cardiac function, basic/clinical(01)(M),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation
• XPS and UPS Studies of Valence Fluctuation and Surface States of Yb_4As_3,Yb_4Sb_3 and Yb_4Bi_3
• Oscillatory High-Field Magnetization in LaP Doped with Ce
• Androgens in human breast carcinoma
• Chicken ovalbumin upstream promoter transcription factor II in human breast carcinoma : Possible regulator of lymphangiogenesis via vascular endothelial growth factor-C expression
• Intratumoral estrogen production in breast carcinoma : significance of aromatase
• Aromatase in Human Breast Carcinoma as a Key Regulator of Intratumoral Sex Steroid Concentrations
• Human liver-specific organic anion transporter-2 is a potent prognostic factor for human breast carcinoma
• In situ production of sex steroids in human breast carcinoma
• Ductal Carcinoma in situ and Related Lesions of the Breast : Recent Advances in Pathology Practice
• Invasive micropapillary carcinoma of the breast : Clinicopathological and immunohistochemical study
• In situ Production of Estrogens in Human Breast Carcinoma
• Immunohistochemical expression of gonadotropin releasing hormone receptor in human breast carcinoma
• Risk factors for vitamin D deficiency in patients with Crohn's disease
• Analysis of cell damage in Helicobacter pylori-associated gastritis
• Chemotherapeutic efficacy of ascofuranone in Trypanosoma vivax-infected mice without glycerol
• Molecular cloning and characterization of Trypanosoma vivax alternative oxidase (AOX) gene, a target of the trypanocide ascofuranone
• The efficacy of ascofuranone in a consecutive treatment on Trypanosoma brucei brucei in mice
• Solid cystic tumor of the pancreas : report of six cases and a review of the Japanese literature
• Steroid and xenobiotic receptor in human esophageal squamous cell carcinoma : A potent prognostic factor
• Inflammatory Mediators Down-Regulate 11β-Hydroxysteroid Dehydrogenase Type 2 in a Human Lung Epithelial Cell Line BEAS-2B and the Rat Lung
• Immunohistopathological and molecular genetic features of a case in which gastrointestinal stromal tumor recurred five times
• Nuclear receptor DAX-1 in human common epithelial ovarian carcinoma : An independent prognostic factor of clinical outcome
• Increased expression of 11β-hydroxysteroid dehydrogenase type 2 in the Iungs of patients with acute respiratory distress syndrome
• Expression of 11β-Hydroxysteroid Dehydrogenase Type 1 in Alveolar Epithelial Cells in Rats
• Photoemission Study of Ce_2Sb
• Heavy Fermion Character in Ce_2Sb and Ce_2Bi
• Sulfatide and Its Synthetic Analogues Recognition by Moraxella catarrhalis
• β-Thujaplicin Zinc Chelate Induces Apoptosis in Mouse High Metastatic Melanoma B16BL6 Cells
• Elastic Properties of Single-Crystalline La_Sr_xCuP_4 : II-C Neutron Scattering, NMR and NQR and Ultrasonics : II Oxide Superconductors; Experiments II : Electronic States
• Instabilities at 1/8 Doping in La_Ba_xCuO_4 and Related Compounds : II-A Instability and Substitution Effects : II Oxide Superconductors; Experiments II : Electronic States
• Resonant Photoemission Studies of Thulium Monochalcogenides around the Tm 4d Threshold
• Frequency of Common Bile Duct Motion Artifacts Caused by Inferior Vena Cava Pulsation on Magnetic Resonance Cholangiopancreatography
• A 5-Year Survivor with 2 Previous Surgical Resections of Extrahepatic Metastases for Hepatocellular Carcinoma after Extended Right Hepatectomy
• Photoemission and Bremsstrahlung from Uranium Compounds : Chapter 4. Optical Properties : 4-1. Photoemission and inverse Photoemission Studies of Electronic Structures
• BIS and XPS Study of YbP,YbAs and Yb_4As_3
• Observation of Heavy Hole State in CeSb
• Effect of a tyrosine kinase inhibitor STI571 in a patient with hepatic metastases from a duodenal gastrointestinal stromal tumor
• Genotype Frequencies of 50 Polymorphisms for 241 Japanese Non-cancer Patients
• Low Expression Myeloperoxidase Genotype Negatively Associated with Helicobacter pylori Infection
• Helicobacter pylori and the t(11;18)(q21;q21) Translocation in Gastric Low-grade B-Cell Lymphoma of Mucosa-associated Lymphoid Tissue Type
• Is CeSb a Low-Carrier Dense Kondo System?
• Anomalous Magnetoresistance in Ce_La_xSb and Ce_La_xBi
• Magnetic Compton of USe Single crystal
• Magnetic Orders in CeP
• Magnetic Polaron Formation in CeP and CeAs
• p-f Mixing and Carrier Number in Ce-Monopnictides
• Heavy Fermion Behavior in Extremely Low Carrier Concentration System Yb_4As_3

もっと見る 閉じる

スポンサーリンク