Vulnerability to Seizures Induced by Potassium Dyshomeostasis in the Hippocampus in Aged Rats
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概要
- 論文の詳細を見る
Neurological diseases such as ischemia and dementia increase with aging, while whether seizure susceptibility increases with aging remains debatable. Seizure activity frequently originates in the hippocampus and is linked to excess of extracellular glutamate. To analyze seizure susceptibility in aged rats, the response of hippocampus excited excessively was evaluated based on extracellular concentrations of neurotransmitters and epileptic behavior. In 8-week-old and 90-100-week-old rats, which exhibited normal passive avoidance behavior, the hippocampus was stimulated with 50-100mM KCl using in vivo microdialysis. The basal concentrations of extracellular glutamate and γ-amino butyric acid (GABA) were almost the same between young and aged rats. The changes in their concentrations after stimulation with 50-100mM KCl were not also appreciably different between them. However, seizures, i.e., myoclonic jerks, were observed only in aged rats during the stimulation. These results suggest that aged rats are vulnerable to seizures induced by dyshomeostasis of potassium and chloride ions in the hippocampal extracellular fluid. Homeostasis of electrolytes in the hippocampal extracellular fluid seems to be important in preventing seizure activity in the elderly.
- 2008-02-01
著者
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TAKEDA Atsushi
Department of Computer Science, Tohoku Bunka Gakuen University
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OKU Naoto
Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka
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Oku Naoto
Department Of Medical Biochemistry And Coe Program In The 21st Century University Of Shizuoka School
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Ando Masaki
Department Of Cardiovascular Surgery Fukushima Red Cross Hospital
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Takeda Atsushi
Department Of Medical Biochemistry School Of Pharmaceutical Sciences University Of Shizuoka
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Takeda Atsushi
Department Of Clinical Pathology Showa University Fujigaoka Hospital Showa University School Of Medi
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Sakurada Naomi
Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka
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Kanno Shingo
Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka
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Kanno Shingo
Department Of Medical Biochemistry School Of Pharmaceutical Sciences University Of Shizuoka
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Sakurada Naomi
Department Of Medical Biochemistry School Of Pharmaceutical Sciences University Of Shizuoka
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Ando Masaki
Department Of Medical Biochemistry School Of Pharmaceutical Sciences University Of Shizuoka
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Oku Naoto
Dep. Of Medical Biochemistry School Of Pharmaceutical Sciences Univ. Of Shizuoka
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TAKEDA Atsushi
Department of Clinical Pathology Showa University Fujigaoka Hospital
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OKU Naoto
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Setsunan University
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