Inhibitory Effect of Liposomal Rhinacanthin-N Isolated from Rhinacanthus nasutus on Pulmonary Metastasis in Mice
スポンサーリンク
概要
- 論文の詳細を見る
We previously observed that rhinacanthins, which are the main naphthoquinone esters isolated from the roots of a Thai medicinal plant, Rhinacanthus nasutus KURZ. (family Acanthaceae), suppress the growth of Meth-A sarcoma in the tumor-bearing mice and that rhinacanthin-N has the strongest antitumor activity among these naphthoquinone esters tested. In the present study, we investigated the effect of rhinacanthin-N on pulmonary metastasis induced by B16F10 melanoma cells in mice. C57BL/6 male mice were injected intravenously with B16F10 melanoma cells, and liposomal rhinacanthin-N was administered intraperitoneally from day 1 to 7 after tumor implantation. Liposomes were used to formulate an injectable form of the hydrophobic agent. Treatment of the mice with 5 or 10 mg/kg/d of liposomal rhinacanthin-N significantly inhibited the pulmonary metastatic colonization of the melanoma cells. Based on these data, our findings demonstrate that rhinacanthin-N possesses antimetastatic efficacy, which may make it a lead compound for the development of a new anticancer drug for use in cancer chemotherapy.
- 公益社団法人 日本薬学会の論文
著者
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Oku Naoto
Department Of Medical Biochemistry And Coe Program In The 21st Century University Of Shizuoka School
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SHIMIZU Kosuke
Department of Medical Biochemistry and COE Program in the 21st Century, School of Pharmaceutical Sci
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Ishii Takayuki
Department Of Biochemistry Hoshi University
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Koide Hiroyuki
Department of Medical Biochemistry and Global COE Program, Graduate School of Pharmaceutical Science
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RUCHIRAWAT Somsak
Laboratory of Medicinal Chemistry, Chulabhorn Research Institute
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Ruchirawat Somsak
Laboratory Of Medicinal Chemistry Chulabhorn Research Institute
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Yahuafai Jantana
Natural Products Research Section Research Division National Cancer Institute
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Siripong Pongpun
Natural Product Research Section Research Division National Cancer Institute
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Piyaviriyakul Suratsawadee
Natural Products Research Section, Research Division, National Cancer Institute
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Kanokmedhakul Kwanjai
Faculty of Science, Khon Kaen University
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Koide Hiroyuki
Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka
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Oku Naoto
Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka
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Shimizu Kosuke
Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka
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Ishii Takayuki
Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka
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OKU Naoto
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Setsunan University
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Ishii Takayuki
Department of Applied Chemistry, Faculty of Engineering, Kanagawa University
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